Biosynthetic potential for polyketides in Talaromyces atroroseus

Kasper Bøwig Rasmussen, Uffe Hasbro Mortensen, Ulf Thrane

    Research output: Contribution to conferencePosterResearchpeer-review

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    Abstract

    Talaromyces atroroseus is an efficient producer of red Monascus pigments. We genome sequenced Talaromyces atroroseus IBT11181 and found it to lack the Monascus pigment PKS with the rest of the Monascus pigment cluster intact. The PKS closest related to the Monascus pigment PKS is the mitorubrin PKS11, and deletion of PKS11 results in the loss of Monascus pigment production. T. atroroseus PKS11 is delivering a precursor for both the mitorubrins and the Monascus pigments. Based on this finding we propose hypothetical models for the evolution of azaphilone pigment PKS clusters in Talaromyces and Monascus.
    Original languageEnglish
    Publication date2014
    Publication statusPublished - 2014
    Event12th European Conference on fungal genetics - Seville, Spain
    Duration: 23 Mar 201427 Mar 2014

    Conference

    Conference12th European Conference on fungal genetics
    CountrySpain
    CitySeville
    Period23/03/201427/03/2014

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