Talaromyces atroroseus is an efficient producer of red Monascus pigments. We genome sequenced Talaromyces atroroseus IBT11181 and found it to lack the Monascus pigment PKS with the rest of the Monascus pigment cluster intact. The PKS closest related to the Monascus pigment PKS is the mitorubrin PKS11, and deletion of PKS11 results in the loss of Monascus pigment production. T. atroroseus PKS11 is delivering a precursor for both the mitorubrins and the Monascus pigments. Based on this finding we propose hypothetical models for the evolution of azaphilone pigment PKS clusters in Talaromyces and Monascus.
|Publication status||Published - 2014|
|Event||12th European Conference on fungal genetics - Seville, Spain|
Duration: 23 Mar 2014 → 27 Mar 2014
|Conference||12th European Conference on fungal genetics|
|Period||23/03/2014 → 27/03/2014|