Biosynthesis of forskolin and related compounds

Björn Hamberger; Birger Lindberg Møller; Eirini Pateraki; Johan Andersen Ranberg; Niels Bjerg Jensen

Biosynthesis of forskolin and related compounds

Björn Hamberger (Inventor), Birger Lindberg Møller (Inventor), Eirini Pateraki (Inventor), Johan Andersen Ranberg (Inventor), Niels Bjerg Jensen (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

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Abstract

The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

Original language	English
IPC	C12P 17/ 06 A I
Patent number	WO2015113569
Filing date	06/08/2016
Country	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	03/09/2014
Priority number	DK20140070536
Publication status	Published - 6 Aug 2015

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WO2015113569A1Final published version, 3.53 MB

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title = "Biosynthesis of forskolin and related compounds",

abstract = "The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.",

author = "Bj{\"o}rn Hamberger and M{\o}ller, {Birger Lindberg} and Eirini Pateraki and Ranberg, {Johan Andersen} and Jensen, {Niels Bjerg}",

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T1 - Biosynthesis of forskolin and related compounds

AU - Hamberger, Björn

AU - Møller, Birger Lindberg

AU - Pateraki, Eirini

AU - Ranberg, Johan Andersen

AU - Jensen, Niels Bjerg

PY - 2015/8/6

Y1 - 2015/8/6

N2 - The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

AB - The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R- MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

M3 - Patent

M1 - WO2015113569

Y2 - 2016/08/06

ER -