Bioprocess intensification: Cases that (don't) work

Luuk A.M. van der Wielen*, Solange I. Mussatto, Jan van Breugel

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Development of affordable and low carbon biobased manufacturing depends critically on strategies that reduce cost and emission profiles. This paper indicates that efforts around the reduction of capital costs by intensification of process equipment need to be carefully weighed against the inherently fast increasing financial and climate costs of driving forces used for the intensification. The fundamental relation between capital expenditures (CAPEX) and operational expenditures (OPEX) of intensified and non-intensified biobased processes and their financial and climatic impacts are emphasized and provisionally explored for a few industrial processes. General learnings flag the importance in particular of OPEX minimisation for sustainable bio-economic development.
Original languageEnglish
JournalNew Biotechnology
Pages (from-to)108-115
Number of pages8
Publication statusPublished - 2021


  • Techno-economic assessment
  • Thermodynamic analysis
  • Integrated biobased manufacturing
  • Bioprocess intensification


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