BIOPRO-Sim: A benchmark simulation model for bio-manufacturing processes

Giorgio Colombo , Isuru A. Udugama, Krist V. Gernaey, Seyed Soheil Mansouri*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review


In this work, an end to end bio-pharmaceutical production process of the API lovastatin is developed through a systematic process synthesis and design approach, and then simulated. The developed simulation is intended to be used as benchmark process model as it captures the generic process dynamics of a bio-pharmaceutical process, and as such it is well-suited to use as a test problem to evaluate different processing scenarios in continuous fermentation processes. The synthesis and design of the simulation is realised through a methodology based on two complimentary steps, that can be applied individually or in conjunction, and is adopted to synthesize the upstream and downstream processing pathway. As such, the process model can be operated either as a whole, or as an individual upstream or downstream process. The open loop response of the whole benchmark simulation is presented here.
Original languageEnglish
Title of host publicationProceedings of the 29th European Symposium on Computer Aided Process Engineering
EditorsKiss Anton, Edwin Zondervan, Richard Lakerveld, Leyla Özkan
Publication date2019
ISBN (Print)9780128186343
Publication statusPublished - 2019
Event29th European Symposium on Computer Aided Process Engineering - Eindhoven, Netherlands
Duration: 16 Jun 201919 Jun 2019


Conference29th European Symposium on Computer Aided Process Engineering
SeriesComputer Aided Chemical Engineering


  • Upstream design
  • Process development
  • Benchmark process model
  • Process modelling and simulation


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