Biopolymers for Antitumor Implantable Drug Delivery Systems: Recent Advances and Future Outlook

Sepehr Talebian, Javad Foroughi, Samantha J. Wade, Kara L. Vine, Alireza Dolatshahi-Pirouz, Mehdi Mehrali, João Conde, Gordon G. Wallace*

*Corresponding author for this work

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    Abstract

    In spite of remarkable improvements in cancer treatments and survivorship, cancer still remains as one of the major causes of death worldwide. Although current standards of care provide encouraging results, they still cause severe systemic toxicity and also fail in preventing recurrence of the disease. In order to address these issues, biomaterial-based implantable drug delivery systems (DDSs) have emerged as promising therapeutic platforms, which allow local administration of drugs directly to the tumor site. Owing to the unique properties of biopolymers, they have been used in a variety of ways to institute biodegradable implantable DDSs that exert precise spatiotemporal control over the release of therapeutic drug. Here, the most recent advances in biopolymer-based DDSs for suppressing tumor growth and preventing tumor recurrence are reviewed. Novel emerging biopolymers as well as cutting-edge polymeric microdevices deployed as implantable antitumor DDSs are discussed. Finally, a review of a new therapeutic modality within the field, which is based on implantable biopolymeric DDSs, is given.
    Original languageEnglish
    Article number1706665
    JournalAdvanced Materials
    Volume30
    Issue number31
    Number of pages31
    ISSN0935-9648
    DOIs
    Publication statusPublished - 2018

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