TY - JOUR
T1 - Biomedical Applications of MXene-Integrated Composites
T2 - Regenerative Medicine, Infection Therapy, Cancer Treatment, and Biosensing
AU - Maleki, Aziz
AU - Ghomi, Matineh
AU - Nikfarjam, Nasser
AU - Akbari, Mahsa
AU - Sharifi, Esmaeel
AU - Shahbazi, Mohammad Ali
AU - Kermanian, Mehraneh
AU - Seyedhamzeh, Mohammed
AU - Nazarzadeh Zare, Ehsan
AU - Mehrali, Mehdi
AU - Moradi, Omid
AU - Sefat, Farshid
AU - Mattoli, Virgilio
AU - Makvandi, Pooyan
AU - Chen, Yu
N1 - Publisher Copyright:
© 2022 The Authors. Advanced Functional Materials published by Wiley-VCH GmbH.
PY - 2022
Y1 - 2022
N2 - MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.
AB - MXenes (viz., transition metal carbides, carbonitrides, and nitrides) have emerged as a new subclass of 2D materials. Due to their outstanding physicochemical and biological properties, MXenes have gained much attention in the biomedical field in recent years, including drug delivery systems, regenerative medicine, and biosensing. Additionally, the incorporation of MXenes into hydrogels has garnered significant interest in biomedical engineering as an electroactive and mechanical nanoreinforcer capable of converting nonconductive scaffolds into excellent conductors of electricity with an impressive effect on mechanical properties for the engineering of electroactive organs and tissues such as cardiac, skeletal muscle, and nerve. However, many questions and problems remain unresolved that need to be answered to usher these 2D materials toward their true destiny. Thus, this review paper aims to provide an overview of the design and applications of MXene-integrated composites for biomedical applications, including cardiac tissue engineering, wound healing, infection therapy, cancer therapy, and biosensors. Moreover, the current challenges and limitations of utilizing MXenes in vivo are highlighted and discussed, followed by its prospects as a guideline toward possible various futuristic biomedical applications. This review article will inspire researchers, who search for properties, opportunities, and challenges of using this 2D nanomaterial in biomedical applications.
KW - 2D materials
KW - Biological properties
KW - Biomedical applications
KW - Integrated composites
KW - MXenes
U2 - 10.1002/adfm.202203430
DO - 10.1002/adfm.202203430
M3 - Review
AN - SCOPUS:85132571371
VL - 32
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 34
M1 - 2203430
ER -