Bioinspired silica as drug delivery systems and their biocompatibility

Christopher R. Steven, Grahame A. Busby, Craig Mather, Balal Tariq, Maria Lucia Briuglia, Dimitrios A. Lamprou, Andrew Urquhart, M. Helen Grant, Siddharth V. Patwardhan

    Research output: Contribution to journalJournal articlepeer-review

    Abstract

    Silica nanoparticles have been shown to have great potential as drug delivery systems (DDS), however, their fabrication often involves harsh chemicals and energy intensive laborious methods. This work details the employment of a bioinspired "green" method for the controlled synthesis of silica, use of the products to entrap and release drug molecules and their cytotoxicity in order to develop novel DDS. Bioinspired silica synthesis occurs at pH 7, room temperature and in less than 5 minutes, resulting in a rapid, cheaper and greener route. Drugs were loaded into silica during the silica formation, thus allowing a one step and one pot method for simultaneous silica synthesis and drug loading. We established that the drug release profile can be modulated by synthetic parameters, which can allow design of tailored DDS. A systematic investigation using a two level factorial design was adopted in order to identify the key synthetic parameters and quantify their effects on silica formation, drug loading and drug release. The observation that these new DDS are considerably less cytotoxic than their current counterparts, and exhibit additional benefits such as green synthesis and ease of functionalization, strengthens the argument for their future use in DDS and other biomedical applications.
    Original languageEnglish
    JournalJournal of Physical Chemistry Part B: Condensed Matter, Materials, Surfaces, Interfaces & Biophysical
    Volume2
    Issue number31
    Pages (from-to)5028-5042
    ISSN1520-6106
    DOIs
    Publication statusPublished - 2014

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