Bioinorganic Chemistry of Zinc in relation to the Immune system

Kasper Planeta Kepp*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

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Abstract

Zinc is well-known to have a central role in human inflammation and immunity and is itself an antiinflammatory and antiviral agent. Despite its massively documented role in such processes, the underlying chemistry of zinc in relation to specific proteins and pathways of the immune system has not received much focus. This short review provides an overview of this topic, with emphasis on the structures of key proteins, zinc coordination chemistry, and probable mechanisms involved in zincbased immunity, with some focus points for future chemical and biological research.
Original languageEnglish
Article numbere202100554
JournalChemBioChem
Volume23
Number of pages15
ISSN1439-4227
DOIs
Publication statusPublished - 2022

Keywords

  • Zinc
  • Immune system
  • Inflammation
  • Virus infections
  • Zinc proteins

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