Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens

Tariq Hisham Beshara Halasa

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    The objective of this study was to assess the epidemiologic and economic consequences of intervention against contagious clinical mastitis during lactation. A bioeconomic model of intramammary infections (IMI) was used to simulate contagious spread of Staphylococcus aureus, Streptococcus uberis, and Streptococcus dysgalactiae, and an environmental spread of Escherichia coli IMI in a 100-cow dairy herd during 1 quota year. The costs of clinical IMI, subclinical IMI, and intervention were calculated into the total annual net costs of IMI during lactation per scenario and compared with a default scenario. Input parameter values were based on the scientific literature. The scenarios were 3-d intramammary lactational treatment (default), 5-d intramammary treatment, 5-d intramammary treatment and 3-d systemic treatment, 3-d intramammary treatment and culling bacteriologically unrecovered clinical IMI cows, and 5-d intramammary treatment and culling bacteriologically unrecovered clinical IMI cows. Sensitivity analysis was conducted on parameter input values. The results showed that interventions including antibiotic treatment combined with culling unrecovered clinical IMI cows resulted in the lowest transmission, number of IMI cases, and persistent subclinical IMI cases. Nonetheless, the high associated costs of culling bacteriologically unrecovered clinical IMI cows made the other scenarios with a long and intensive antibiotic treatment, but without culling, the most cost effective. The model was sensitive to changes to the cure rate of clinical IMI following treatment, but the ranking of the intervention scenarios did not change. The model was most sensitive to the changes to the transmission rate of Staph. aureus. The ranking of the intervention scenarios changed at low transmission rate of this pathogen, in which the default scenario became the most cost-effective scenario. In case of high transmission of contagious IMI pathogens, long and intensive treatment of clinical IMI should be preceded by strategies that lower the transmission.
    Original languageEnglish
    JournalJournal of Dairy Science
    Volume95
    Issue number10
    Pages (from-to)5740-5749
    ISSN0022-0302
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Clinical mastitis
    • Treatment
    • Economic model
    • Transmission

    Fingerprint Dive into the research topics of 'Bioeconomic modeling of intervention against clinical mastitis caused by contagious pathogens'. Together they form a unique fingerprint.

    Cite this