Biodistribution of Carbon Nanotubes in Animal Models

Nicklas Raun Jacobsen, Peter Horn Møller, Per Axel Clausen, Anne Thoustrup Saber, Christian Micheletti, Keld Alstrup Jensen, Hakan Wallin, Ulla Birgitte Vogel

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    Abstract

    The many interesting physical and chemical properties of carbon nanotubes (CNT) make it one of the most commercially attractive materials in the era of nanotechnology. Here, we review the recent publications on in vivo biodistribution of pristine and functionalized forms of single-walled and multi-walled CNT. Pristine CNT remain in the lung for months or even years after pulmonary deposition. If cleared, the majority of CNT move to the gastrointestinal (GI) tract via the mucociliary escalator. However, there appears to be no uptake of CNT from the GI tract, with a possible exception of the smallest functionalized SWCNT. Importantly, a significant fraction of CNT translocate from the alveolar space to the near pulmonary region including lymph nodes, subpleura and pleura (<7% of the pulmonary deposited dose) and to distal organs including liver, spleen and bone marrow (~1%). These results clearly demonstrate the main sites of long-term CNT accumulation, which also includes pleura, a major site for fibre-induced pulmonary diseases. Studies on intravenous injection show that CNT in blood circulation are cleared relatively fast with a half-life of minutes or hours. The major target organs were the same as identified after pulmonary exposure with the exception of urine excretion of especially functionalized SWCNT and accumulation in lung tissue. Overall, there is evidence that CNT will primarily be distributed to the liver where they appear to be present at least one year after exposure.
    Original languageEnglish
    JournalBasic & Clinical Pharmacology & Toxicology
    Volume121
    Pages (from-to)30-43
    Number of pages14
    ISSN1742-7835
    DOIs
    Publication statusPublished - 2017

    Cite this

    Jacobsen, N. R., Møller, P. H., Clausen, P. A., Saber, A. T., Micheletti, C., Jensen, K. A., Wallin, H., & Vogel, U. B. (2017). Biodistribution of Carbon Nanotubes in Animal Models. Basic & Clinical Pharmacology & Toxicology, 121, 30-43. https://doi.org/10.1111/bcpt.12705