Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration

Abbas Mokhtari‐Farsani, Masoud Hasany, Iseult Lynch, Mehdi Mehrali*

*Corresponding author for this work

    Research output: Contribution to journalJournal articleResearchpeer-review

    143 Downloads (Pure)


    It has been over a decade since oxidative enzymes were first used to degrade carbon-based nanomaterials (CBNs). Although enormous progress has been achieved in this field, many questions and problems remain unresolved that need to be answered to usher these materials toward their true destiny. Nanobioscience researchers now know that ignoring the biomolecular corona (BMC) in nanobiomedical studies, either inadvertently or intentionally, is by no means justified. However, a major drawback to progress is that BMC effects on CBN biodegradation have been omitted from a large number of studies. What's more, many studies in the field have eliminated the BMC source in the relevant experiments. Thus, the most critical question that one needs to probe is whether the BMC and its characteristics affect the biodegradability of CBNs? In this conceptual perspective paper, recent progress and significant research in CBNs biodegradation are summarized. Then, the importance of the BMC and its possible impacts on the biodegradation of CBNs are thoroughly explored as a conceptual guide. Finally, remaining challenges and the direction of future research are provided, and barriers that need to be overcome to advance the field are discussed including recommendations regarding BMC considerations and study design and reporting guidelines.
    Original languageEnglish
    Article number2105649
    JournalAdvanced Functional Materials
    Issue number6
    Number of pages21
    Publication statusPublished - 2022


    Dive into the research topics of 'Biodegradation of Carbon‐Based Nanomaterials: The Importance of “Biomolecular Corona” Consideration'. Together they form a unique fingerprint.

    Cite this