Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin

Charlotte Frydenlund Michelsen, Helle Jensen, Vincent J. Venditto, Rosanna C. Hennessy, Peter Stougaard

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    Abstract

    Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp. In5 is a biocontrol strain isolated from a plant disease suppressive soil in Greenland, which produces two antimicrobial nonribosomal peptides (NRPs), nunapeptin and nunamycin. In this study, we used in vitro antimicrobial and anticancer bioassays to evaluate the potential bioactivities of both a crude extract derived from Pseudomonas sp. In5 and NRPs purified from the crude extract.
    Original languageEnglish
    Article numbere1476
    JournalPeerJ
    Volume3
    Number of pages16
    ISSN2167-8359
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

    Distributed under Creative Commons CC-BY 4.0

    Keywords

    • Crude extract
    • Nonribosomal peptides
    • Antimicrobial
    • Anticancer
    • Pseudomonas

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