Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin

Charlotte Frydenlund Michelsen; Helle Jensen; Vincent J. Venditto; Rosanna C. Hennessy; Peter Stougaard

doi:10.7717/peerj.1476

Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin

Charlotte Frydenlund Michelsen, Helle Jensen, Vincent J. Venditto, Rosanna C. Hennessy, Peter Stougaard

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Abstract

Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp. In5 is a biocontrol strain isolated from a plant disease suppressive soil in Greenland, which produces two antimicrobial nonribosomal peptides (NRPs), nunapeptin and nunamycin. In this study, we used in vitro antimicrobial and anticancer bioassays to evaluate the potential bioactivities of both a crude extract derived from Pseudomonas sp. In5 and NRPs purified from the crude extract.

Original language	English
Article number	e1476
Journal	PeerJ
Volume	3
Number of pages	16
ISSN	2167-8359
DOIs	https://doi.org/10.7717/peerj.1476
Publication status	Published - 2015

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Distributed under Creative Commons CC-BY 4.0

Keywords

Crude extract
Nonribosomal peptides
Antimicrobial
Anticancer
Pseudomonas

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title = "Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin",

abstract = "Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp. In5 is a biocontrol strain isolated from a plant disease suppressive soil in Greenland, which produces two antimicrobial nonribosomal peptides (NRPs), nunapeptin and nunamycin. In this study, we used in vitro antimicrobial and anticancer bioassays to evaluate the potential bioactivities of both a crude extract derived from Pseudomonas sp. In5 and NRPs purified from the crude extract.",

keywords = "Crude extract, Nonribosomal peptides, Antimicrobial, Anticancer, Pseudomonas",

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AU - Frydenlund Michelsen, Charlotte

AU - Jensen, Helle

AU - Venditto, Vincent J.

AU - Hennessy, Rosanna C.

AU - Stougaard, Peter

N1 - Distributed under Creative Commons CC-BY 4.0

PY - 2015

Y1 - 2015

N2 - Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp. In5 is a biocontrol strain isolated from a plant disease suppressive soil in Greenland, which produces two antimicrobial nonribosomal peptides (NRPs), nunapeptin and nunamycin. In this study, we used in vitro antimicrobial and anticancer bioassays to evaluate the potential bioactivities of both a crude extract derived from Pseudomonas sp. In5 and NRPs purified from the crude extract.

AB - Bioactive microbial metabolites provide a successful source of novel compounds with pharmaceutical potentials. The bacterium Pseudomonas sp. In5 is a biocontrol strain isolated from a plant disease suppressive soil in Greenland, which produces two antimicrobial nonribosomal peptides (NRPs), nunapeptin and nunamycin. In this study, we used in vitro antimicrobial and anticancer bioassays to evaluate the potential bioactivities of both a crude extract derived from Pseudomonas sp. In5 and NRPs purified from the crude extract.

KW - Crude extract

KW - Nonribosomal peptides

KW - Antimicrobial

KW - Anticancer

KW - Pseudomonas

U2 - 10.7717/peerj.1476

DO - 10.7717/peerj.1476

M3 - Journal article

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JO - PeerJ

JF - PeerJ

M1 - e1476

ER -

Bioactivities by a crude extract from the Greenlandic Pseudomonas sp. In5 involves the nonribosomal peptides, nunamycin and nunapeptin

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Keywords

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