Bio Optofluidics Cell Sorter – cell-BOCS Concept and Applications

Tue Roth, Jesper Glückstad

Research output: Contribution to journalConference articleResearchpeer-review

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Abstract

The cell-BOCS is a novel microfluidics based cell-sorting instrument utilizing next generation optical trapping technology developed at the Technical University of Denmark. It is targeted emerging bio-medical research and diagnostics markets where it for certain applications offers a number of advantages over conventional fluorescence activated cell-sorting (FACS™) technology. Advantages include gentle handling of cells, sterile sorting, easy operation, small footprint and lower cost allowing out-of-core-facility use. Application examples are found within sorting of fragile transfected cells, high value samples and primary cell lines, where traditional FACS technology has limited application due to it’s droplet-based approach to cell-sorting. In the diagnostics field, in particular applying the cell-BOCS for isolating pure populations of circulating tumor cells is an area that has generated a lot of interest.
Original languageEnglish
JournalProceedings of SPIE, the International Society for Optical Engineering
Volume8274
Pages (from-to)82740J
ISSN0277-786X
DOIs
Publication statusPublished - 2012
EventSPIE Photonics West - The Moscone Center, San Francisco, California, United States
Duration: 21 Jan 201226 Jan 2012

Conference

ConferenceSPIE Photonics West
LocationThe Moscone Center
CountryUnited States
CitySan Francisco, California
Period21/01/201226/01/2012

Keywords

  • Flow cytometry
  • Microfluidics
  • Optical tweezers
  • Fluorescence activated cell sorting
  • Optical trapping

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