Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges

Satoshi Yuzawa, Jay D. Keasling, Leonard Katz

Research output: Contribution to journalReviewResearchpeer-review

Abstract

Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.
Original languageEnglish
JournalThe Journal of Antibiotics
Volume70
Pages (from-to)378-385
ISSN0021-8820
DOIs
Publication statusPublished - 2017

Cite this

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title = "Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges",
abstract = "Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.",
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pages = "378--385",
journal = "The Journal of Antibiotics",
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Bio-based production of fuels and industrial chemicals by repurposing antibiotic-producing type I modular polyketide synthases: opportunities and challenges. / Yuzawa, Satoshi; Keasling, Jay D.; Katz, Leonard.

In: The Journal of Antibiotics, Vol. 70, 2017, p. 378-385.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

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AU - Yuzawa, Satoshi

AU - Keasling, Jay D.

AU - Katz, Leonard

PY - 2017

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N2 - Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

AB - Complex polyketides comprise a large number of natural products that have broad application in medicine and agriculture. They are produced in bacteria and fungi from large enzyme complexes named type I modular polyketide synthases (PKSs) that are composed of multifunctional polypeptides containing discrete enzymatic domains organized into modules. The modular nature of PKSs has enabled a multitude of efforts to engineer the PKS genes to produce novel polyketides of predicted structure. We have repurposed PKSs to produce a number of short-chain mono- and di-carboxylic acids and ketones that could have applications as fuels or industrial chemicals.

U2 - 10.1038/ja.2016.136

DO - 10.1038/ja.2016.136

M3 - Review

C2 - 27847387

VL - 70

SP - 378

EP - 385

JO - The Journal of Antibiotics

JF - The Journal of Antibiotics

SN - 0021-8820

ER -