Binding of hydrophobic antigens to surfaces

Ulrik Boas (Inventor)

    Research output: Patent

    314 Downloads (Pure)

    Abstract

    A first aspect of the present invention is a method of detecting antibodies comprising the steps of: i) providing a first group of beads comprising a surface modified with C1-C10 alkyl groups comprising amine, ammonium, ether and/or hydroxyl groups, ii) contacting said first group of beads with a first hydrophobic antigen to provide a first group of bead-antigen conjugates by adsorption of the first hydrophobic antigen on the first group of beads, iii) isolating said bead- antigen conjugates, iv) contacting said bead-antigen conjugates with a sample to bind antibodies therein to provide bead-antigen-antibody conjugates, and v) detecting said bead-antigen-antibody conjugates. Further aspects include an antibody detection kit, a bead-antigen conjugate and a composition comprising at least two different groups of bead-antigen-conjugates.

    Original languageEnglish
    IPCG01N 33/ 543 A I
    Patent numberWO2017042303
    Filing date16/03/2017
    CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
    Priority date08/09/2015
    Priority numberEP20150184294
    Publication statusPublished - 16 Mar 2017

    Cite this

    Boas, U. (2017). IPC No. G01N 33/ 543 A I. Binding of hydrophobic antigens to surfaces. (Patent No. WO2017042303).
    Boas, Ulrik (Inventor). / Binding of hydrophobic antigens to surfaces. IPC No.: G01N 33/ 543 A I. Patent No.: WO2017042303. Mar 16, 2017.
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    Boas, U Mar. 16 2017, Binding of hydrophobic antigens to surfaces, Patent No. WO2017042303, IPC No. G01N 33/ 543 A I.

    Binding of hydrophobic antigens to surfaces. / Boas, Ulrik (Inventor).

    IPC No.: G01N 33/ 543 A I. Patent No.: WO2017042303. Mar 16, 2017.

    Research output: Patent

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    T1 - Binding of hydrophobic antigens to surfaces

    AU - Boas, Ulrik

    PY - 2017/3/16

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    N2 - A first aspect of the present invention is a method of detecting antibodies comprising the steps of: i) providing a first group of beads comprising a surface modified with C1-C10 alkyl groups comprising amine, ammonium, ether and/or hydroxyl groups, ii) contacting said first group of beads with a first hydrophobic antigen to provide a first group of bead-antigen conjugates by adsorption of the first hydrophobic antigen on the first group of beads, iii) isolating said bead- antigen conjugates, iv) contacting said bead-antigen conjugates with a sample to bind antibodies therein to provide bead-antigen-antibody conjugates, and v) detecting said bead-antigen-antibody conjugates. Further aspects include an antibody detection kit, a bead-antigen conjugate and a composition comprising at least two different groups of bead-antigen-conjugates.

    AB - A first aspect of the present invention is a method of detecting antibodies comprising the steps of: i) providing a first group of beads comprising a surface modified with C1-C10 alkyl groups comprising amine, ammonium, ether and/or hydroxyl groups, ii) contacting said first group of beads with a first hydrophobic antigen to provide a first group of bead-antigen conjugates by adsorption of the first hydrophobic antigen on the first group of beads, iii) isolating said bead- antigen conjugates, iv) contacting said bead-antigen conjugates with a sample to bind antibodies therein to provide bead-antigen-antibody conjugates, and v) detecting said bead-antigen-antibody conjugates. Further aspects include an antibody detection kit, a bead-antigen conjugate and a composition comprising at least two different groups of bead-antigen-conjugates.

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    Boas U, inventor. Binding of hydrophobic antigens to surfaces. G01N 33/ 543 A I. 2017 Mar 16.