Bimodal oscillations in nephron autoregulation

Olga Sosnovtseva, A.N. Pavlov, Erik Mosekilde, N.H. Holstein-Rathlou

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Abstract

The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: fast oscillations associated with a myogenic dynamics of the afferent arteriole, and slower oscillations arising from a delay in the tubuloglomerular feedback. We investigate the intra- and internephron entrainment of the two time scales. In addition to full synchronization, both wavelet analyses of experimental data and numerical simulations reveal a partial entrainment in which neighboring nephrons attain a state of chaotic synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.
Original languageEnglish
JournalPhysical Review E. Statistical, Nonlinear, and Soft Matter Physics
Volume66
Issue number6
Pages (from-to)061909
ISSN1063-651X
DOIs
Publication statusPublished - 2002

Bibliographical note

Copyright (2002) American Physical Society

Keywords

  • SYNCHRONIZATION
  • SPONTANEOUSLY HYPERTENSIVE RATS
  • TUBULOGLOMERULAR FEEDBACK
  • DYNAMICS
  • PRESSURE
  • FLOW REGULATION

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