Bimodal oscillations in nephron autoregulation

Olga Sosnovtseva; A.N. Pavlov; Erik Mosekilde; N.H. Holstein-Rathlou

doi:10.1103/PhysRevE.66.061909

Bimodal oscillations in nephron autoregulation

Olga Sosnovtseva, A.N. Pavlov, Erik Mosekilde, N.H. Holstein-Rathlou

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Abstract

The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: fast oscillations associated with a myogenic dynamics of the afferent arteriole, and slower oscillations arising from a delay in the tubuloglomerular feedback. We investigate the intra- and internephron entrainment of the two time scales. In addition to full synchronization, both wavelet analyses of experimental data and numerical simulations reveal a partial entrainment in which neighboring nephrons attain a state of chaotic synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.

Original language	English
Journal	Physical Review E. Statistical, Nonlinear, and Soft Matter Physics
Volume	66
Issue number	6
Pages (from-to)	061909
ISSN	1063-651X
DOIs	https://doi.org/10.1103/PhysRevE.66.061909
Publication status	Published - 2002

Bibliographical note

Copyright (2002) American Physical Society

Keywords

SYNCHRONIZATION
SPONTANEOUSLY HYPERTENSIVE RATS
TUBULOGLOMERULAR FEEDBACK
DYNAMICS
PRESSURE
FLOW REGULATION

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title = "Bimodal oscillations in nephron autoregulation",

abstract = "The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: fast oscillations associated with a myogenic dynamics of the afferent arteriole, and slower oscillations arising from a delay in the tubuloglomerular feedback. We investigate the intra- and internephron entrainment of the two time scales. In addition to full synchronization, both wavelet analyses of experimental data and numerical simulations reveal a partial entrainment in which neighboring nephrons attain a state of chaotic synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.",

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AU - Sosnovtseva, Olga

AU - Pavlov, A.N.

AU - Mosekilde, Erik

AU - Holstein-Rathlou, N.H.

N1 - Copyright (2002) American Physical Society

PY - 2002

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N2 - The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: fast oscillations associated with a myogenic dynamics of the afferent arteriole, and slower oscillations arising from a delay in the tubuloglomerular feedback. We investigate the intra- and internephron entrainment of the two time scales. In addition to full synchronization, both wavelet analyses of experimental data and numerical simulations reveal a partial entrainment in which neighboring nephrons attain a state of chaotic synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.

AB - The individual functional unit of the kidney (the nephron) displays oscillations in its pressure and flow regulation at two different time scales: fast oscillations associated with a myogenic dynamics of the afferent arteriole, and slower oscillations arising from a delay in the tubuloglomerular feedback. We investigate the intra- and internephron entrainment of the two time scales. In addition to full synchronization, both wavelet analyses of experimental data and numerical simulations reveal a partial entrainment in which neighboring nephrons attain a state of chaotic synchronization with respect to their slow dynamics, but the fast dynamics remain desynchronized.

KW - SYNCHRONIZATION

KW - SPONTANEOUSLY HYPERTENSIVE RATS

KW - TUBULOGLOMERULAR FEEDBACK

KW - DYNAMICS

KW - PRESSURE

KW - FLOW REGULATION

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DO - 10.1103/PhysRevE.66.061909

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JO - Physical Review E. Statistical, Nonlinear, and Soft Matter Physics

JF - Physical Review E. Statistical, Nonlinear, and Soft Matter Physics

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Bimodal oscillations in nephron autoregulation

Abstract

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Keywords

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