Bifurcation structure of a model of bursting pancreatic cells

Erik Mosekilde, B. Lading, S. Yanchuk, Y. Maistrenko

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

One- and two-dimensional bifurcation studies of a prototypic model of bursting oscillations in pancreatic P-cells reveal a squid-formed area of chaotic dynamics in the parameter plane, with period-doubling bifurcations on one side of the arms and saddle-node bifurcations on the other. The transition from this structure to the so-called period-adding structure is found to involve a subcritical period-doubling bifurcation and the emergence of type-III intermittency. The period-adding transition itself is not smooth but consists of a saddle-node bifurcation in which (n + 1)-spike bursting behavior is born, slightly overlapping with a subcritical period-doubling bifurcation in which n-spike bursting behavior loses its stability.
Original languageEnglish
JournalBioSystems
Volume63
Issue number1-13
Pages (from-to)3-13
ISSN0303-2647
Publication statusPublished - 2001

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