Biased distribution of DNA uptake sequences towards genome maintenance genes

T. Davidsen, E.A. Rodland, K. Lagesen, E. Seeberg, Torbjørn Rognes, T. Tonjum

    Research output: Contribution to journalJournal articleResearchpeer-review


    Repeated sequence signatures are characteristic features of all genomic DNA. We have made a rigorous search for repeat genomic sequences in the human pathogens Neisseria meningitidis, Neisseria gonorrhoeae and Haemophilus influenzae and found that by far the most frequent 9-10mers residing within coding regions are the DNA uptake sequences (DUS) required for natural genetic transformation. More importantly, we found a significantly higher density of DUS within genes involved in DNA repair, recombination, restriction-modification and replication than in any other annotated gene group in these organisms. Pasteurella multocida also displayed high frequencies of a putative DUS identical to that previously identified in H. influenzae and with a skewed distribution towards genome maintenance genes, indicating that this bacterium might be transformation competent under certain conditions.
    Original languageEnglish
    JournalNucleic Acids Research
    Pages (from-to)1050-1058
    Publication statusPublished - 2004


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