Beyond Genetic Engineering: Technical Capabilities in the Application Fields of Biocatalysis and Biosensors

Christopher E. French; Louise Horsfall; Damian K. Barnard; Kwabena Duedu; Eugene Fletcher; Nimisha Joshi; Steven D. Kane; Sahreena S. Lakhundi; Chao-Kuo Liu; Jan Oltmanns; David Radford; Alejandro Salinas; Joseph White; Alistair Elfick; B. Giese; C. Pade; H. Wigger; A. VonGleich

doi:10.1007/978-3-319-02783-8_6

Beyond Genetic Engineering: Technical Capabilities in the Application Fields of Biocatalysis and Biosensors

Christopher E. French, Louise Horsfall, Damian K. Barnard, Kwabena Duedu, Eugene Fletcher, Nimisha Joshi, Steven D. Kane, Sahreena S. Lakhundi, Chao-Kuo Liu, Jan Oltmanns, David Radford, Alejandro Salinas, Joseph White, Alistair Elfick, B. Giese (Editor), C. Pade (Editor), H. Wigger (Editor), A. VonGleich (Editor)

University of Edinburgh

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

Abstract

Synthetic biology allows the generation of complex recombinant systems using libraries of modular components. Two major near-market applications are whole-cell biosensors and biocatalysts for conversion of lignocellulosic biomass to biofuels and chemical feedstocks. Whole cell biosensors consist of cells genetically modified so that binding of a specific analyte to a receptor in the cell triggers generation of a specific output which can be detected and quantified. Since these systems are intrinsically modular in nature, with separate systems for signal detection, signal processing, and generation of the output, they are well suited to a synthetic biology approach. Likewise, effective degradation of cellulosic biomass requires a battery of different enzymes working together to degrade the matrix, expose the polysaccharide fibres, hydrolyse these to release sugars, and convert the sugars to useful products. Synthetic biology provides a useful set of tools to generate such systems. In this chapter we consider how synthetic biology has been applied to these applications, and look at possible future developments in these areas.

Original language	English
Title of host publication	Synthetic Biology : Character and Impact
Editors	Bernd Giese, Christian Pade, Henning Wigger, Arnim von Gleich
Number of pages	25
Publisher	Springer
Publication date	2015
Pages	113-137
ISBN (Print)	978-3-319-02782-1
ISBN (Electronic)	978-3-319-02783-8
DOIs	https://doi.org/10.1007/978-3-319-02783-8_6
Publication status	Published - 2015
Externally published	Yes

Series	Risk Engineering
ISSN	2195-433X

Keywords

Biomedical engineering
Genetic engineering
Quality Control
Reliability
Safety
Risk
Energy

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10.1007/978-3-319-02783-8_6

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French, C. E., Horsfall, L., Barnard, D. K., Duedu, K., Fletcher, E., Joshi, N., Kane, S. D., Lakhundi, S. S., Liu, C.-K., Oltmanns, J., Radford, D., Salinas, A., White, J., Elfick, A., Giese, B. (Ed.), Pade, C. (Ed.), Wigger, H. (Ed.), & VonGleich, A. (Ed.) (2015). Beyond Genetic Engineering: Technical Capabilities in the Application Fields of Biocatalysis and Biosensors. In B. Giese, C. Pade, H. Wigger, & A. von Gleich (Eds.), Synthetic Biology: Character and Impact (pp. 113-137). Springer. https://doi.org/10.1007/978-3-319-02783-8_6

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abstract = "Synthetic biology allows the generation of complex recombinant systems using libraries of modular components. Two major near-market applications are whole-cell biosensors and biocatalysts for conversion of lignocellulosic biomass to biofuels and chemical feedstocks. Whole cell biosensors consist of cells genetically modified so that binding of a specific analyte to a receptor in the cell triggers generation of a specific output which can be detected and quantified. Since these systems are intrinsically modular in nature, with separate systems for signal detection, signal processing, and generation of the output, they are well suited to a synthetic biology approach. Likewise, effective degradation of cellulosic biomass requires a battery of different enzymes working together to degrade the matrix, expose the polysaccharide fibres, hydrolyse these to release sugars, and convert the sugars to useful products. Synthetic biology provides a useful set of tools to generate such systems. In this chapter we consider how synthetic biology has been applied to these applications, and look at possible future developments in these areas.",

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author = "French, {Christopher E.} and Louise Horsfall and Barnard, {Damian K.} and Kwabena Duedu and Eugene Fletcher and Nimisha Joshi and Kane, {Steven D.} and Lakhundi, {Sahreena S.} and Chao-Kuo Liu and Jan Oltmanns and David Radford and Alejandro Salinas and Joseph White and Alistair Elfick and B. Giese and C. Pade and H. Wigger and A. VonGleich",

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doi = "10.1007/978-3-319-02783-8_6",

language = "English",

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French, CE, Horsfall, L, Barnard, DK, Duedu, K, Fletcher, E, Joshi, N, Kane, SD, Lakhundi, SS, Liu, C-K, Oltmanns, J, Radford, D, Salinas, A, White, J, Elfick, A, Giese, B (ed.), Pade, C (ed.), Wigger, H (ed.) & VonGleich, A (ed.) 2015, Beyond Genetic Engineering: Technical Capabilities in the Application Fields of Biocatalysis and Biosensors. in B Giese, C Pade, H Wigger & A von Gleich (eds), Synthetic Biology: Character and Impact. Springer, Risk Engineering, pp. 113-137. https://doi.org/10.1007/978-3-319-02783-8_6

Beyond Genetic Engineering: Technical Capabilities in the Application Fields of Biocatalysis and Biosensors. / French, Christopher E.; Horsfall, Louise; Barnard, Damian K. et al.
Synthetic Biology: Character and Impact. ed. / Bernd Giese; Christian Pade; Henning Wigger; Arnim von Gleich. Springer, 2015. p. 113-137 (Risk Engineering).

Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research › peer-review

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AU - Radford, David

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KW - Risk

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Beyond Genetic Engineering: Technical Capabilities in the Application Fields of Biocatalysis and Biosensors

Abstract

Keywords

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