Bead Capture on Magnetic Sensors in a Microfluidic System

Frederik Westergaard Østerberg, Bjarke Thomas Dalslet, Christian Danvad Damsgaard, S. C. Freitas, P. P. Freitas, Mikkel Fougt Hansen

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    Abstract

    The accumulation of magnetic beads by gravitational sedimentation and magnetic capture on a planar Hall-effect sensor integrated in a microfluidic channel is studied systematically as a function of the bead concentration, the fluid flow rate, and the sensor bias current. It is demonstrated that the sedimentation flux is proportional to the bead concentration and has a power law relation to the fluid flow rate. The mechanisms for the bead accumulation are investigated and it is found that gravitational sedimentation dominates the bead accumulation, whereas the stability of the sedimented beads against the fluid flow is defined by the localized magnetic fields from the sensor.
    Original languageEnglish
    JournalIEEE Sensors Journal
    Volume9
    Issue number5-6
    Pages (from-to)682-688
    ISSN1530-437X
    DOIs
    Publication statusPublished - 2009

    Bibliographical note

    Copyright: 2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

    Keywords

    • microfluidic
    • bead
    • lab-on-a-chip
    • AMR
    • biosensor

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