Bead Capture on Magnetic Sensors in a Microfluidic System

Frederik Westergaard Østerberg; Bjarke Thomas Dalslet; Christian Danvad Damsgaard; S. C. Freitas; P. P. Freitas; Mikkel Fougt Hansen

doi:10.1109/JSEN.2009.2021122

Bead Capture on Magnetic Sensors in a Microfluidic System

Frederik Westergaard Østerberg, Bjarke Thomas Dalslet, Christian Danvad Damsgaard, S. C. Freitas, P. P. Freitas, Mikkel Fougt Hansen

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Abstract

The accumulation of magnetic beads by gravitational sedimentation and magnetic capture on a planar Hall-effect sensor integrated in a microfluidic channel is studied systematically as a function of the bead concentration, the fluid flow rate, and the sensor bias current. It is demonstrated that the sedimentation flux is proportional to the bead concentration and has a power law relation to the fluid flow rate. The mechanisms for the bead accumulation are investigated and it is found that gravitational sedimentation dominates the bead accumulation, whereas the stability of the sedimented beads against the fluid flow is defined by the localized magnetic fields from the sensor.

Original language	English
Journal	IEEE Sensors Journal
Volume	9
Issue number	5-6
Pages (from-to)	682-688
ISSN	1530-437X
DOIs	https://doi.org/10.1109/JSEN.2009.2021122
Publication status	Published - 2009

Bibliographical note

Copyright: 2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

Keywords

microfluidic
bead
lab-on-a-chip
AMR
biosensor

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10.1109/JSEN.2009.2021122

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title = "Bead Capture on Magnetic Sensors in a Microfluidic System",

abstract = "The accumulation of magnetic beads by gravitational sedimentation and magnetic capture on a planar Hall-effect sensor integrated in a microfluidic channel is studied systematically as a function of the bead concentration, the fluid flow rate, and the sensor bias current. It is demonstrated that the sedimentation flux is proportional to the bead concentration and has a power law relation to the fluid flow rate. The mechanisms for the bead accumulation are investigated and it is found that gravitational sedimentation dominates the bead accumulation, whereas the stability of the sedimented beads against the fluid flow is defined by the localized magnetic fields from the sensor.",

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note = "Copyright: 2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE",

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AU - Østerberg, Frederik Westergaard

AU - Dalslet, Bjarke Thomas

AU - Damsgaard, Christian Danvad

AU - Freitas, S. C.

AU - Freitas, P. P.

AU - Hansen, Mikkel Fougt

N1 - Copyright: 2009 IEEE. Personal use of this material is permitted. However, permission to reprint/republish this material for advertising or promotional purposes or for creating new collective works for resale or redistribution to servers or lists, or to reuse any copyrighted component of this work in other works must be obtained from the IEEE

PY - 2009

Y1 - 2009

N2 - The accumulation of magnetic beads by gravitational sedimentation and magnetic capture on a planar Hall-effect sensor integrated in a microfluidic channel is studied systematically as a function of the bead concentration, the fluid flow rate, and the sensor bias current. It is demonstrated that the sedimentation flux is proportional to the bead concentration and has a power law relation to the fluid flow rate. The mechanisms for the bead accumulation are investigated and it is found that gravitational sedimentation dominates the bead accumulation, whereas the stability of the sedimented beads against the fluid flow is defined by the localized magnetic fields from the sensor.

AB - The accumulation of magnetic beads by gravitational sedimentation and magnetic capture on a planar Hall-effect sensor integrated in a microfluidic channel is studied systematically as a function of the bead concentration, the fluid flow rate, and the sensor bias current. It is demonstrated that the sedimentation flux is proportional to the bead concentration and has a power law relation to the fluid flow rate. The mechanisms for the bead accumulation are investigated and it is found that gravitational sedimentation dominates the bead accumulation, whereas the stability of the sedimented beads against the fluid flow is defined by the localized magnetic fields from the sensor.

KW - microfluidic

KW - bead

KW - lab-on-a-chip

KW - AMR

KW - biosensor

U2 - 10.1109/JSEN.2009.2021122

DO - 10.1109/JSEN.2009.2021122

M3 - Journal article

SN - 1530-437X

VL - 9

SP - 682

EP - 688

JO - IEEE Sensors Journal

JF - IEEE Sensors Journal

IS - 5-6

ER -

Bead Capture on Magnetic Sensors in a Microfluidic System

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