Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence

Zhongli Xu, Martin Baunach, Ling Ding, Christian Hertweck

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Getting indole terpenes into shape: Genetic analysis, pathway dissection, and heterologous reconstitution provide first insights into bacterial indolosesquiterpenoid biosynthesis and unveil the involvement of a new type of terpene cyclase and an indole oxygenase in the formation of indosespene, xiamycin, and sespenine ring systems. Furthermore, heterologous pathway expression led to the discovery of C-C- and C-N-linked xiamycin dimers. 
Original languageEnglish
JournalAngewandte chemie-international edition
Volume51
Issue number41
Pages (from-to)10293-10297
Number of pages5
ISSN1433-7851
DOIs
Publication statusPublished - 2012
Externally publishedYes

Keywords

  • Alkaloids
  • Indole Oxygenase
  • Indolosesquiterpenes
  • Terpene Cyclase
  • Xiamycin

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