Bacteria subsisting on antibiotics.

Gautam Dantas, Morten O A Sommer, Rantimi D. Oluwasegun, George M. Church

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Antibiotics are a crucial line of defense against bacterial infections. Nevertheless, several antibiotics are natural products of microorganisms that have as yet poorly appreciated ecological roles in the wider environment. We isolated hundreds of soil bacteria with the capacity to grow on antibiotics as a sole carbon source. Of 18 antibiotics tested, representing eight major classes of natural and synthetic origin, 13 to 17 supported the growth of clonal bacteria from each of 11 diverse soils. Bacteria subsisting on antibiotics are surprisingly phylogenetically diverse, and many are closely related to human pathogens. Furthermore, each antibiotic-consuming isolate was resistant to multiple antibiotics at clinically relevant concentrations. This phenomenon suggests that this unappreciated reservoir of antibiotic-resistance determinants can contribute to the increasing levels of multiple antibiotic resistance in pathogenic bacteria.
Original languageEnglish
JournalScience
Volume320
Issue number5872
Pages (from-to)100-103
ISSN0036-8075
DOIs
Publication statusPublished - 2008
Externally publishedYes

Cite this

Dantas, G., Sommer, M. O. A., Oluwasegun, R. D., & Church, G. M. (2008). Bacteria subsisting on antibiotics. Science, 320(5872), 100-103. https://doi.org/10.1126/science.1155157