Background and Organ on a Chip

Martin Dufva*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review

Abstract

The most widespread cell culture devices such as flasks and titer plate do not fully represent the human physiology. Furthermore, the titer plates have difficulties to interconnect many organs together into an organ system. The motivation for interconnecting organ models is to better predict observations in vitro with the corresponding human reaction. Currently, experimental animals are used to get information on the organism levels. However, there are compelling data showing that there is a poor correlation between results in the animal and the corresponding reaction in humans. The human organ on a chip (HOOC) concept provides a path to replace experimental animal and to better understand relationship and effects between organs. The long-term goal of these HOOCs is to use patient- and donor-derived stem cells and build tiny artificial organs and connect them together to get system-level information. There is a large body of evidence suggesting that these precise, often microfluidics-based, organ models functionally outperform corresponding cultures using traditional methods. The gains of these HOOC are likely caused by excellent mass transfer, ability to position different cell types together and to connect organs in a physiological manner.

Original languageEnglish
Title of host publicationMicrofluidics and Multi Organs on Chip
PublisherSpringer
Publication date2022
Pages185-197
Chapter8
ISBN (Print)9789811913785
ISBN (Electronic)9789811913792
DOIs
Publication statusPublished - 2022

Keywords

  • Human physiology
  • Human-on-a-chip
  • Microfluidics
  • Organ-on-a-chip

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