BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Research output: Contribution to journalJournal article – Annual report year: 2018Researchpeer-review

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DOI

  • Author: Dudnik, Alexey

    Microbial Evolution and Synthetic Biology, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Almeida, A. Filipa

    Instituto de Biologia Experimental e Tecnológica

  • Author: Andrade, Ricardo

    Institut National de Recherche en Informatique et en Automatique

  • Author: Avila, Barbara

    Pontificia Universidad Catolica de Chile

  • Author: Bañados, Pilar

    Pontificia Universidad Catolica de Chile

  • Author: Barbay, Diane

    Evolva SA

  • Author: Bassard, Jean Étienne

    University of Copenhagen

  • Author: Benkoulouche, Mounir

    Evolva SA

  • Author: Bott, Michael

    Jülich Research Centre

  • Author: Braga, Adelaide

    Biotempo

  • Author: Breitel, Dario

    John Innes Centre

  • Author: Brennan, Rex

    The James Hutton Institute

  • Author: Bulteau, Laurent

    Institut National de Recherche en Informatique et en Automatique

  • Author: Chanforan, Celine

    Chr. Hansen AS

  • Author: Costa, Inês

    Instituto de Biologia Experimental e Tecnológica

  • Author: Costa, Rafael S.

    University of Lisbon

  • Author: Doostmohammadi, Mahdi

    University of Lisbon

  • Author: Faria, Nuno R.

    Biotempo

  • Author: Feng, Chengyong

    CAS - Institute of Botany

  • Author: Fernandes, Armando

    University of Lisbon

  • Author: Ferreira, Patricia

    Biotempo, Portugal

  • Author: Ferro, Roberto

    Microbial Evolution and Synthetic Biology, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, 2800, Kgs.Lyngby, Denmark

  • Author: Foito, Alexandre

    The James Hutton Institute

  • Author: Freitag, Sabine

    The James Hutton Institute

  • Author: Garcia, Gonçalo

    Instituto de Biologia Experimental e Tecnológica

  • Author: Gaspar, Paula

    Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 4, 2970, Hørsholm, Denmark

  • Author: Godinho-Pereira, Joana

    Instituto de Biologia Experimental e Tecnológica

  • Author: Hamberger, Björn

    University of Copenhagen, Denmark

  • Author: Hartmann, Andras

    University of Lisbon

  • Author: Heider, Harald

    Evolva SA

  • Author: Jardim, Carolina

    Instituto de Biologia Experimental e Tecnológica

  • Author: Julien-Laferriere, Alice

    Institut National de Recherche en Informatique et en Automatique

  • Author: Kallscheuer, Nicolai

    Jülich Research Centre

  • Author: Kerbe, Wolfgang

    Biofaction KG

  • Author: Kuipers, Oscar P.

    University of Groningen

  • Author: Li, Shanshan

    CAS - Institute of Botany

  • Author: Love, Nicola

    John Innes Centre

  • Author: Marchetti-Spaccamela, Alberto

    Institut National de Recherche en Informatique et en Automatique

  • Author: Marienhagen, Jan

    Jülich Research Centre

  • Author: Martin, Cathie

    John Innes Centre

  • Author: Mary, Arnaud

    Institut National de Recherche en Informatique et en Automatique

  • Author: Mazurek, Vincent

    Chr. Hansen AS

  • Author: Meinhart, Camillo

    Biofaction KG

  • Author: Sevillano, David Méndez

    Delft University of Technology

  • Author: Menezes, Regina

    Instituto de Biologia Experimental e Tecnológica

  • Author: Naesby, Michael

    Evolva SA

  • Author: Nørholm, Morten H.H.

    Microbial Evolution and Synthetic Biology, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kemitorvet, 2800, Kgs. Lyngby, Denmark

  • Author: Okkels, Finn Thyge

    Chr. Hansen AS

  • Author: Oliveira, Joana

    Biotempo

  • Author: Ottens, Marcel

    Delft University of Technology

  • Author: Parrot, Delphine

    Institut National de Recherche en Informatique et en Automatique

  • Author: Pei, Lei

    Biofaction KG

  • Author: Rocha, Isabel

    Biotempo

  • Author: Rosado-Ramos, Rita

    Instituto de Biologia Experimental e Tecnológica

  • Author: Rousseau, Caroline

    Evolva SA

  • Author: Sagot, Marie France

    Institut National de Recherche en Informatique et en Automatique

  • Author: Dos Santos, Claudia Nunes

    Instituto de Biologia Experimental e Tecnológica

  • Author: Schmidt, Markus

    Biofaction KG

  • Author: Shelenga, Tatiana

    N.I.Vavilov Research Institute of Plant Industry

  • Author: Shepherd, Louise V.T.

    The James Hutton Institute

  • Author: Silva, Ana Rita

    Biotempo

  • Author: da Silva, Marcelo Henriques

    Delft University of Technology

  • Author: Simon, Olivier

    Chr. Hansen AS

  • Author: Stahlhut, Steen Gustav

    Applied Metabolic Engineering, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 4, 2970, Hørsholm, Denmark

  • Author: Solopova, Ana

    University of Groningen

  • Author: Sorokin, Artem

    N.I.Vavilov Research Institute of Plant Industry

  • Author: Stewart, Derek

    The James Hutton Institute

  • Author: Stougie, Leen

    University of Edinburgh

  • Author: Su, Shang

    CAS - Institute of Botany

  • Author: Thole, Vera

    John Innes Centre

  • Author: Tikhonova, Olga

    N.I.Vavilov Research Institute of Plant Industry

  • Author: Trick, Martin

    John Innes Centre

  • Author: Vain, Philippe

    John Innes Centre

  • Author: Veríssimo, André

    University of Lisbon

  • Author: Vila-Santa, Ana

    University of Lisbon

  • Author: Vinga, Susana

    University of Lisbon

  • Author: Vogt, Michael

    Jülich Research Centre

  • Author: Wang, Liangsheng

    CAS - Institute of Botany

  • Author: Wang, Lijin

    CAS - Institute of Botany

  • Author: Wei, Wei

    CAS - Institute of Botany

  • Author: Youssef, Sandra

    Biofaction KG

  • Author: Neves, Ana Rute

    Chr. Hansen AS, Denmark

  • Author: Forster, Jochen

    Applied Metabolic Engineering, Research Groups, Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kogle Allé 6, 2970, Hørsholm, Denmark

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BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

Original languageEnglish
JournalPhytochemistry Reviews
Volume17
Issue number2
Pages (from-to)291-326
Number of pages36
ISSN1568-7767
DOIs
Publication statusPublished - 2018
CitationsWeb of Science® Times Cited: No match on DOI

    Research areas

  • Berries, Bioprospecting, Microbial cell factories, Polyphenols, Sustainable production

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