BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

Alexey Dudnik*, A. Filipa Almeida, Ricardo Andrade, Barbara Avila, Pilar Bañados, Diane Barbay, Jean Etienne Bassard, Mounir Benkoulouche, Michael Bott, Adelaide Braga, Dario Breitel, Rex Brennan, Laurent Bulteau, Celine Chanforan, Inês Costa, Rafael S. Costa, Mahdi Doostmohammadi, Nuno Faria, Chengyong Feng, Armando Fernandes & 63 others Patricia Ferreira, Roberto Ferro, Alexandre Foito, Sabine Freitag, Gonçalo Garcia, Paula Gaspar, Joana Godinho-Pereira, Björn Hamberger, András Hartmann, Harald Heider, Carolina Jardim, Alice Julien-Laferriere, Nicolai Kallscheuer, Wolfgang Kerbe, Oscar P. Kuipers, Shanshan Li, Nicola Love, Alberto Marchetti-Spaccamela, Jan Marienhagen, Cathie Martin, Arnaud Mary, Vincent Mazurek, Camillo Meinhart, David Méndez Sevillano, Regina Menezes, Michael Naesby, Morten H.H. Nørholm, Finn T. Okkels, Joana Oliveira, Marcel Ottens, Delphine Parrot, Lei Pei, Isabel Rocha, Rita Rosado-Ramos, Caroline Rousseau, Marie France Sagot, Claudia Nunes Dos Santos, Markus Schmidt, Tatiana Shelenga, Louise Shepherd, Ana Rita Silva, Marcelo Henriques da Silva, Olivier Simon, Steen Gustav Stahlhut, Ana Solopova, Artem Sorokin, Derek Stewart, Leen Stougie, Shang Su, Vera Thole, Olga Tikhonova, Martin Trick, Philippe Vain, André Veríssimo, Ana Vila-Santa, Susana Vinga, Michael Vogt, Liangsheng Wang, Lijin Wang, Wei Wei, Sandra Youssef, Ana Rute Neves, Jochen Forster

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

Original languageEnglish
JournalPhytochemistry Reviews
Volume17
Issue number2
Pages (from-to)291-326
Number of pages36
ISSN1568-7767
DOIs
Publication statusPublished - 2018

Keywords

  • Berries
  • Bioprospecting
  • Microbial cell factories
  • Polyphenols
  • Sustainable production

Cite this

Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., ... Forster, J. (2018). BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits. Phytochemistry Reviews, 17(2), 291-326. https://doi.org/10.1007/s11101-017-9532-2
Dudnik, Alexey ; Almeida, A. Filipa ; Andrade, Ricardo ; Avila, Barbara ; Bañados, Pilar ; Barbay, Diane ; Bassard, Jean Etienne ; Benkoulouche, Mounir ; Bott, Michael ; Braga, Adelaide ; Breitel, Dario ; Brennan, Rex ; Bulteau, Laurent ; Chanforan, Celine ; Costa, Inês ; Costa, Rafael S. ; Doostmohammadi, Mahdi ; Faria, Nuno ; Feng, Chengyong ; Fernandes, Armando ; Ferreira, Patricia ; Ferro, Roberto ; Foito, Alexandre ; Freitag, Sabine ; Garcia, Gonçalo ; Gaspar, Paula ; Godinho-Pereira, Joana ; Hamberger, Björn ; Hartmann, András ; Heider, Harald ; Jardim, Carolina ; Julien-Laferriere, Alice ; Kallscheuer, Nicolai ; Kerbe, Wolfgang ; Kuipers, Oscar P. ; Li, Shanshan ; Love, Nicola ; Marchetti-Spaccamela, Alberto ; Marienhagen, Jan ; Martin, Cathie ; Mary, Arnaud ; Mazurek, Vincent ; Meinhart, Camillo ; Sevillano, David Méndez ; Menezes, Regina ; Naesby, Michael ; Nørholm, Morten H.H. ; Okkels, Finn T. ; Oliveira, Joana ; Ottens, Marcel ; Parrot, Delphine ; Pei, Lei ; Rocha, Isabel ; Rosado-Ramos, Rita ; Rousseau, Caroline ; Sagot, Marie France ; Dos Santos, Claudia Nunes ; Schmidt, Markus ; Shelenga, Tatiana ; Shepherd, Louise ; Silva, Ana Rita ; da Silva, Marcelo Henriques ; Simon, Olivier ; Stahlhut, Steen Gustav ; Solopova, Ana ; Sorokin, Artem ; Stewart, Derek ; Stougie, Leen ; Su, Shang ; Thole, Vera ; Tikhonova, Olga ; Trick, Martin ; Vain, Philippe ; Veríssimo, André ; Vila-Santa, Ana ; Vinga, Susana ; Vogt, Michael ; Wang, Liangsheng ; Wang, Lijin ; Wei, Wei ; Youssef, Sandra ; Neves, Ana Rute ; Forster, Jochen. / BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits. In: Phytochemistry Reviews. 2018 ; Vol. 17, No. 2. pp. 291-326.
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title = "BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits",
abstract = "BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.",
keywords = "Berries, Bioprospecting, Microbial cell factories, Polyphenols, Sustainable production",
author = "Alexey Dudnik and Almeida, {A. Filipa} and Ricardo Andrade and Barbara Avila and Pilar Ba{\~n}ados and Diane Barbay and Bassard, {Jean Etienne} and Mounir Benkoulouche and Michael Bott and Adelaide Braga and Dario Breitel and Rex Brennan and Laurent Bulteau and Celine Chanforan and In{\^e}s Costa and Costa, {Rafael S.} and Mahdi Doostmohammadi and Nuno Faria and Chengyong Feng and Armando Fernandes and Patricia Ferreira and Roberto Ferro and Alexandre Foito and Sabine Freitag and Gon{\cc}alo Garcia and Paula Gaspar and Joana Godinho-Pereira and Bj{\"o}rn Hamberger and Andr{\'a}s Hartmann and Harald Heider and Carolina Jardim and Alice Julien-Laferriere and Nicolai Kallscheuer and Wolfgang Kerbe and Kuipers, {Oscar P.} and Shanshan Li and Nicola Love and Alberto Marchetti-Spaccamela and Jan Marienhagen and Cathie Martin and Arnaud Mary and Vincent Mazurek and Camillo Meinhart and Sevillano, {David M{\'e}ndez} and Regina Menezes and Michael Naesby and N{\o}rholm, {Morten H.H.} and Okkels, {Finn T.} and Joana Oliveira and Marcel Ottens and Delphine Parrot and Lei Pei and Isabel Rocha and Rita Rosado-Ramos and Caroline Rousseau and Sagot, {Marie France} and {Dos Santos}, {Claudia Nunes} and Markus Schmidt and Tatiana Shelenga and Louise Shepherd and Silva, {Ana Rita} and {da Silva}, {Marcelo Henriques} and Olivier Simon and Stahlhut, {Steen Gustav} and Ana Solopova and Artem Sorokin and Derek Stewart and Leen Stougie and Shang Su and Vera Thole and Olga Tikhonova and Martin Trick and Philippe Vain and Andr{\'e} Ver{\'i}ssimo and Ana Vila-Santa and Susana Vinga and Michael Vogt and Liangsheng Wang and Lijin Wang and Wei Wei and Sandra Youssef and Neves, {Ana Rute} and Jochen Forster",
year = "2018",
doi = "10.1007/s11101-017-9532-2",
language = "English",
volume = "17",
pages = "291--326",
journal = "Phytochemistry Reviews",
issn = "1568-7767",
publisher = "Springer Netherlands",
number = "2",

}

Dudnik, A, Almeida, AF, Andrade, R, Avila, B, Bañados, P, Barbay, D, Bassard, JE, Benkoulouche, M, Bott, M, Braga, A, Breitel, D, Brennan, R, Bulteau, L, Chanforan, C, Costa, I, Costa, RS, Doostmohammadi, M, Faria, N, Feng, C, Fernandes, A, Ferreira, P, Ferro, R, Foito, A, Freitag, S, Garcia, G, Gaspar, P, Godinho-Pereira, J, Hamberger, B, Hartmann, A, Heider, H, Jardim, C, Julien-Laferriere, A, Kallscheuer, N, Kerbe, W, Kuipers, OP, Li, S, Love, N, Marchetti-Spaccamela, A, Marienhagen, J, Martin, C, Mary, A, Mazurek, V, Meinhart, C, Sevillano, DM, Menezes, R, Naesby, M, Nørholm, MHH, Okkels, FT, Oliveira, J, Ottens, M, Parrot, D, Pei, L, Rocha, I, Rosado-Ramos, R, Rousseau, C, Sagot, MF, Dos Santos, CN, Schmidt, M, Shelenga, T, Shepherd, L, Silva, AR, da Silva, MH, Simon, O, Stahlhut, SG, Solopova, A, Sorokin, A, Stewart, D, Stougie, L, Su, S, Thole, V, Tikhonova, O, Trick, M, Vain, P, Veríssimo, A, Vila-Santa, A, Vinga, S, Vogt, M, Wang, L, Wang, L, Wei, W, Youssef, S, Neves, AR & Forster, J 2018, 'BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits', Phytochemistry Reviews, vol. 17, no. 2, pp. 291-326. https://doi.org/10.1007/s11101-017-9532-2

BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits. / Dudnik, Alexey; Almeida, A. Filipa; Andrade, Ricardo; Avila, Barbara; Bañados, Pilar; Barbay, Diane; Bassard, Jean Etienne; Benkoulouche, Mounir; Bott, Michael; Braga, Adelaide; Breitel, Dario; Brennan, Rex; Bulteau, Laurent; Chanforan, Celine; Costa, Inês; Costa, Rafael S.; Doostmohammadi, Mahdi; Faria, Nuno; Feng, Chengyong; Fernandes, Armando; Ferreira, Patricia; Ferro, Roberto; Foito, Alexandre; Freitag, Sabine; Garcia, Gonçalo; Gaspar, Paula; Godinho-Pereira, Joana; Hamberger, Björn; Hartmann, András; Heider, Harald; Jardim, Carolina; Julien-Laferriere, Alice; Kallscheuer, Nicolai; Kerbe, Wolfgang; Kuipers, Oscar P.; Li, Shanshan; Love, Nicola; Marchetti-Spaccamela, Alberto; Marienhagen, Jan; Martin, Cathie; Mary, Arnaud; Mazurek, Vincent; Meinhart, Camillo; Sevillano, David Méndez; Menezes, Regina; Naesby, Michael; Nørholm, Morten H.H.; Okkels, Finn T.; Oliveira, Joana; Ottens, Marcel; Parrot, Delphine; Pei, Lei; Rocha, Isabel; Rosado-Ramos, Rita; Rousseau, Caroline; Sagot, Marie France; Dos Santos, Claudia Nunes; Schmidt, Markus; Shelenga, Tatiana; Shepherd, Louise; Silva, Ana Rita; da Silva, Marcelo Henriques; Simon, Olivier; Stahlhut, Steen Gustav; Solopova, Ana; Sorokin, Artem; Stewart, Derek; Stougie, Leen; Su, Shang; Thole, Vera; Tikhonova, Olga; Trick, Martin; Vain, Philippe; Veríssimo, André; Vila-Santa, Ana; Vinga, Susana; Vogt, Michael; Wang, Liangsheng; Wang, Lijin; Wei, Wei; Youssef, Sandra; Neves, Ana Rute; Forster, Jochen.

In: Phytochemistry Reviews, Vol. 17, No. 2, 2018, p. 291-326.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - BacHBerry:: BACterial Hosts for production of Bioactive phenolics from bERRY fruits

AU - Dudnik, Alexey

AU - Almeida, A. Filipa

AU - Andrade, Ricardo

AU - Avila, Barbara

AU - Bañados, Pilar

AU - Barbay, Diane

AU - Bassard, Jean Etienne

AU - Benkoulouche, Mounir

AU - Bott, Michael

AU - Braga, Adelaide

AU - Breitel, Dario

AU - Brennan, Rex

AU - Bulteau, Laurent

AU - Chanforan, Celine

AU - Costa, Inês

AU - Costa, Rafael S.

AU - Doostmohammadi, Mahdi

AU - Faria, Nuno

AU - Feng, Chengyong

AU - Fernandes, Armando

AU - Ferreira, Patricia

AU - Ferro, Roberto

AU - Foito, Alexandre

AU - Freitag, Sabine

AU - Garcia, Gonçalo

AU - Gaspar, Paula

AU - Godinho-Pereira, Joana

AU - Hamberger, Björn

AU - Hartmann, András

AU - Heider, Harald

AU - Jardim, Carolina

AU - Julien-Laferriere, Alice

AU - Kallscheuer, Nicolai

AU - Kerbe, Wolfgang

AU - Kuipers, Oscar P.

AU - Li, Shanshan

AU - Love, Nicola

AU - Marchetti-Spaccamela, Alberto

AU - Marienhagen, Jan

AU - Martin, Cathie

AU - Mary, Arnaud

AU - Mazurek, Vincent

AU - Meinhart, Camillo

AU - Sevillano, David Méndez

AU - Menezes, Regina

AU - Naesby, Michael

AU - Nørholm, Morten H.H.

AU - Okkels, Finn T.

AU - Oliveira, Joana

AU - Ottens, Marcel

AU - Parrot, Delphine

AU - Pei, Lei

AU - Rocha, Isabel

AU - Rosado-Ramos, Rita

AU - Rousseau, Caroline

AU - Sagot, Marie France

AU - Dos Santos, Claudia Nunes

AU - Schmidt, Markus

AU - Shelenga, Tatiana

AU - Shepherd, Louise

AU - Silva, Ana Rita

AU - da Silva, Marcelo Henriques

AU - Simon, Olivier

AU - Stahlhut, Steen Gustav

AU - Solopova, Ana

AU - Sorokin, Artem

AU - Stewart, Derek

AU - Stougie, Leen

AU - Su, Shang

AU - Thole, Vera

AU - Tikhonova, Olga

AU - Trick, Martin

AU - Vain, Philippe

AU - Veríssimo, André

AU - Vila-Santa, Ana

AU - Vinga, Susana

AU - Vogt, Michael

AU - Wang, Liangsheng

AU - Wang, Lijin

AU - Wei, Wei

AU - Youssef, Sandra

AU - Neves, Ana Rute

AU - Forster, Jochen

PY - 2018

Y1 - 2018

N2 - BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

AB - BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

KW - Berries

KW - Bioprospecting

KW - Microbial cell factories

KW - Polyphenols

KW - Sustainable production

U2 - 10.1007/s11101-017-9532-2

DO - 10.1007/s11101-017-9532-2

M3 - Journal article

VL - 17

SP - 291

EP - 326

JO - Phytochemistry Reviews

JF - Phytochemistry Reviews

SN - 1568-7767

IS - 2

ER -