TY - JOUR
T1 - Axonal loss occurs early in dominant optic atrophy
AU - Milea, Dan
AU - Sander, Birgit
AU - Wegener, Marianne
AU - Jensen, Hanne
AU - Kjer, Birgit
AU - Jørgensen, Thomas Martini
AU - Lund-Andersen, Henrik
AU - Larsen, Michael
PY - 2010
Y1 - 2010
N2 - Purpose: This study set out to investigate retinal nerve fibre layer (RNFL)
thickness and best corrected visual acuity (BCVA) in relation to age in
healthy subjects and patients with OPA1 autosomal dominant optic atrophy
(DOA).
Methods: We carried out a cross-sectional investigation of RNFL thickness
and ganglion cell layer density in 30 healthy subjects and 10 patients with
OPA1 DOA using optical coherence tomography (OCT). We then performed
a regression analysis of RNFL thickness and BCVA versus age.
Results: Both healthy subjects and DOA patients demonstrated a gradual
reduction in RNFL thickness with age; the relationship was best described statistically
by a model that assumed a constant offset between the two groups.
Best corrected VA decreased significantly with age in DOA patients, in whom
BCVA was correlated with peripapillary RNFL thickness in the inferior and
superior peripapillary quadrants and with total macular thickness at eccentricities
of 500–3000 lm. The observations were best described by a constant offset
of 41.9 lm separating the two groups and an annual decrease in RNFL
thickness of 0.48 lm (p <0.0001). In patients with DOA, increasing age was
associated with decreasing BCVA (p = 0.046).
Conclusions: This cross-sectional study found evidence of comparable agerelated
decreases in RNFL thickness in healthy subjects and in DOA
patients, where the deficit in DOA patients is best described using a model
that assumes the deficit between the groups does not vary with age. The
gradual reduction of BCVA with age may be a consequence of a relative
deficit in RNFL thickness that is established before the second decade of
life.
AB - Purpose: This study set out to investigate retinal nerve fibre layer (RNFL)
thickness and best corrected visual acuity (BCVA) in relation to age in
healthy subjects and patients with OPA1 autosomal dominant optic atrophy
(DOA).
Methods: We carried out a cross-sectional investigation of RNFL thickness
and ganglion cell layer density in 30 healthy subjects and 10 patients with
OPA1 DOA using optical coherence tomography (OCT). We then performed
a regression analysis of RNFL thickness and BCVA versus age.
Results: Both healthy subjects and DOA patients demonstrated a gradual
reduction in RNFL thickness with age; the relationship was best described statistically
by a model that assumed a constant offset between the two groups.
Best corrected VA decreased significantly with age in DOA patients, in whom
BCVA was correlated with peripapillary RNFL thickness in the inferior and
superior peripapillary quadrants and with total macular thickness at eccentricities
of 500–3000 lm. The observations were best described by a constant offset
of 41.9 lm separating the two groups and an annual decrease in RNFL
thickness of 0.48 lm (p <0.0001). In patients with DOA, increasing age was
associated with decreasing BCVA (p = 0.046).
Conclusions: This cross-sectional study found evidence of comparable agerelated
decreases in RNFL thickness in healthy subjects and in DOA
patients, where the deficit in DOA patients is best described using a model
that assumes the deficit between the groups does not vary with age. The
gradual reduction of BCVA with age may be a consequence of a relative
deficit in RNFL thickness that is established before the second decade of
life.
KW - uden tema
U2 - 10.1111/j.1755-3768.2008.01469.x
DO - 10.1111/j.1755-3768.2008.01469.x
M3 - Journal article
C2 - 19302076
SN - 1755-375X
VL - 88
SP - 342
EP - 346
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
IS - 3
ER -