Autonomous cryogenic RF receive coil for 13C imaging of rodents at 3 T

Juan Diego Sánchez-Heredia*, Rafael Antonio Baron, Esben Søvsø Szocska Hansen, Christoffer Laustsen, Vitaliy Zhurbenko, Jan Henrik Ardenkjær-Larsen

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Purpose: To develop an autonomous, in-bore, MR-compatible cryostat cooled with liquid nitrogen that provides full-day operation, and to demonstrate that the theoretical signal-to-noise benefit can be achieved for 13C imaging at 3 T (32.13 MHz).
Methods: The cryogenic setup uses a vacuum-insulated fiberglass cryostat, which indirectly cools a cold finger where the RF coil is attached. The cryostat was evacuated before use and had a reservoir of liquid nitrogen for full-day operation. A 30 × 40 mm2 copper coil was mounted inside the cryostat with a 3-mm distance to the sample. Two examples of in vivo experiments of rat brain metabolism after a hyperpolarized [1-13C]pyruvate injection are reported. Results: A coil Q-factor ratio of Q88K/Q290K = 550/280 was obtained, and the theoretical SNR enhancement was verified with MR measurements. We achieved a coil temperature of 88 K and a preamplifier temperature of 77 K. A 2-fold overall SNR enhancement was achieved, compared with the best case at room temperature. The thermal performance of the coil was adequate for in vivo experiments, with an autonomy of 5 hours consuming 6 L of LN2, extendable to over 12 hours by LN2 refilling.
Conclusion: Cryogenic surface coils can be highly beneficial for 13C imaging, provided that the coil-to-sample distance remains short. An autonomous, in-bore cryostat was developed that achieved the theoretical improvement in SNR.
Original languageEnglish
JournalMagnetic Resonance in Medicine
Number of pages12
ISSN0740-3194
DOIs
Publication statusAccepted/In press - 2020

Keywords

  • 13C MRI
  • Cryogenic
  • Hyperpolarization
  • RF coil
  • SNR

Cite this

@article{d8f7655294b44f70ae1b768e8d884083,
title = "Autonomous cryogenic RF receive coil for 13C imaging of rodents at 3 T",
abstract = "Purpose: To develop an autonomous, in-bore, MR-compatible cryostat cooled with liquid nitrogen that provides full-day operation, and to demonstrate that the theoretical signal-to-noise benefit can be achieved for 13C imaging at 3 T (32.13 MHz). Methods: The cryogenic setup uses a vacuum-insulated fiberglass cryostat, which indirectly cools a cold finger where the RF coil is attached. The cryostat was evacuated before use and had a reservoir of liquid nitrogen for full-day operation. A 30 × 40 mm2 copper coil was mounted inside the cryostat with a 3-mm distance to the sample. Two examples of in vivo experiments of rat brain metabolism after a hyperpolarized [1-13C]pyruvate injection are reported. Results: A coil Q-factor ratio of Q88K/Q290K = 550/280 was obtained, and the theoretical SNR enhancement was verified with MR measurements. We achieved a coil temperature of 88 K and a preamplifier temperature of 77 K. A 2-fold overall SNR enhancement was achieved, compared with the best case at room temperature. The thermal performance of the coil was adequate for in vivo experiments, with an autonomy of 5 hours consuming 6 L of LN2, extendable to over 12 hours by LN2 refilling. Conclusion: Cryogenic surface coils can be highly beneficial for 13C imaging, provided that the coil-to-sample distance remains short. An autonomous, in-bore cryostat was developed that achieved the theoretical improvement in SNR.",
keywords = "13C MRI, Cryogenic, Hyperpolarization, RF coil, SNR",
author = "S{\'a}nchez-Heredia, {Juan Diego} and Baron, {Rafael Antonio} and Hansen, {Esben S{\o}vs{\o} Szocska} and Christoffer Laustsen and Vitaliy Zhurbenko and Ardenkj{\ae}r-Larsen, {Jan Henrik}",
year = "2020",
doi = "10.1002/mrm.28113",
language = "English",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "JohnWiley & Sons, Inc.",

}

Autonomous cryogenic RF receive coil for 13C imaging of rodents at 3 T. / Sánchez-Heredia, Juan Diego; Baron, Rafael Antonio; Hansen, Esben Søvsø Szocska; Laustsen, Christoffer; Zhurbenko, Vitaliy; Ardenkjær-Larsen, Jan Henrik.

In: Magnetic Resonance in Medicine, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Autonomous cryogenic RF receive coil for 13C imaging of rodents at 3 T

AU - Sánchez-Heredia, Juan Diego

AU - Baron, Rafael Antonio

AU - Hansen, Esben Søvsø Szocska

AU - Laustsen, Christoffer

AU - Zhurbenko, Vitaliy

AU - Ardenkjær-Larsen, Jan Henrik

PY - 2020

Y1 - 2020

N2 - Purpose: To develop an autonomous, in-bore, MR-compatible cryostat cooled with liquid nitrogen that provides full-day operation, and to demonstrate that the theoretical signal-to-noise benefit can be achieved for 13C imaging at 3 T (32.13 MHz). Methods: The cryogenic setup uses a vacuum-insulated fiberglass cryostat, which indirectly cools a cold finger where the RF coil is attached. The cryostat was evacuated before use and had a reservoir of liquid nitrogen for full-day operation. A 30 × 40 mm2 copper coil was mounted inside the cryostat with a 3-mm distance to the sample. Two examples of in vivo experiments of rat brain metabolism after a hyperpolarized [1-13C]pyruvate injection are reported. Results: A coil Q-factor ratio of Q88K/Q290K = 550/280 was obtained, and the theoretical SNR enhancement was verified with MR measurements. We achieved a coil temperature of 88 K and a preamplifier temperature of 77 K. A 2-fold overall SNR enhancement was achieved, compared with the best case at room temperature. The thermal performance of the coil was adequate for in vivo experiments, with an autonomy of 5 hours consuming 6 L of LN2, extendable to over 12 hours by LN2 refilling. Conclusion: Cryogenic surface coils can be highly beneficial for 13C imaging, provided that the coil-to-sample distance remains short. An autonomous, in-bore cryostat was developed that achieved the theoretical improvement in SNR.

AB - Purpose: To develop an autonomous, in-bore, MR-compatible cryostat cooled with liquid nitrogen that provides full-day operation, and to demonstrate that the theoretical signal-to-noise benefit can be achieved for 13C imaging at 3 T (32.13 MHz). Methods: The cryogenic setup uses a vacuum-insulated fiberglass cryostat, which indirectly cools a cold finger where the RF coil is attached. The cryostat was evacuated before use and had a reservoir of liquid nitrogen for full-day operation. A 30 × 40 mm2 copper coil was mounted inside the cryostat with a 3-mm distance to the sample. Two examples of in vivo experiments of rat brain metabolism after a hyperpolarized [1-13C]pyruvate injection are reported. Results: A coil Q-factor ratio of Q88K/Q290K = 550/280 was obtained, and the theoretical SNR enhancement was verified with MR measurements. We achieved a coil temperature of 88 K and a preamplifier temperature of 77 K. A 2-fold overall SNR enhancement was achieved, compared with the best case at room temperature. The thermal performance of the coil was adequate for in vivo experiments, with an autonomy of 5 hours consuming 6 L of LN2, extendable to over 12 hours by LN2 refilling. Conclusion: Cryogenic surface coils can be highly beneficial for 13C imaging, provided that the coil-to-sample distance remains short. An autonomous, in-bore cryostat was developed that achieved the theoretical improvement in SNR.

KW - 13C MRI

KW - Cryogenic

KW - Hyperpolarization

KW - RF coil

KW - SNR

U2 - 10.1002/mrm.28113

DO - 10.1002/mrm.28113

M3 - Journal article

C2 - 31782552

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

ER -