Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI

Koen Van Leemput, Akram Bakkour, Thomas Benner, Graham Wiggins, Lawrence L. Wald, Jean Augustinack, Bradford C. Dickerson, Polina Golland, Bruce Fischl

Research output: Contribution to journalConference abstract in journalResearchpeer-review


Recent developments in MRI data acquisition technology are starting to yield images that show anatomical features of the hippocampal formation at an unprecedented level of detail, providing the basis for hippocampal subfield measurement. However, a fundamental bottleneck in MRI studies of the hippocampus at the subfield level is that they currently depend on manual segmentation, a laborious process that severely limits the amount of data that can be analyzed. In this article, we present a computational method for segmenting the hippocampal subfields in ultra-high resolution MRI data in a fully automated fashion. Using Bayesian inference, we use a statistical model of image formation around the hippocampal area to obtain automated segmentations. We validate the proposed technique by comparing its segmentations to corresponding manual delineations in ultra-high resolution MRI scans of 10 individuals, and show that automated volume measurements of the larger subfields correlate well with manual volume estimates. Unlike manual segmentations, our automated technique is fully reproducible, and fast enough to enable routine analysis of the hippocampal subfields in large imaging studies. © 2009 Wiley-Liss, Inc.
Original languageEnglish
JournalThe Hippocampus
Issue number6
Pages (from-to)549-557
Number of pages9
Publication statusPublished - 2009
Externally publishedYes
Event1st Computational Hippocampal Anatomy and Physiology Workshop - New York, NY, United States
Duration: 6 Sep 2008 → …
Conference number: 1


Workshop1st Computational Hippocampal Anatomy and Physiology Workshop
CountryUnited States
CityNew York, NY
Period06/09/2008 → …

Cite this

Van Leemput, K., Bakkour, A., Benner, T., Wiggins, G., Wald, L. L., Augustinack, J., Dickerson, B. C., Golland, P., & Fischl, B. (2009). Automated segmentation of hippocampal subfields from ultra-high resolution in vivo MRI. The Hippocampus, 19(6), 549-557.