Automated Quantification of Retinal Microvasculature from OCT Angiography using Dictionary-Based Vessel Segmentation

Astrid Margareta Elisabet Engberg*, Jesper H. Erichsen, Birgit Sander, Line Kessel, Anders Bjorholm Dahl, Vedrana Andersen Dahl

*Corresponding author for this work

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Abstract

Investigations in how the retinal microvasculature correlates with ophthalmological conditions necessitate a method for measuring the microvasculature. Optical coherence tomography angiography (OCTA) depicts the superficial and the deep layer of the retina, but quantification of the microvascular network is still needed. Here, we propose an automatic quantitative analysis of the retinal microvasculature. We use a dictionary-based segmentation to detect larger vessels and capillaries in the retina and we extract features such as densities and vessel radius. The method is validated on repeated OCTA scans from healthy subjects, and we observe high intraclass correlation coecients and high agreement in a Bland-Altman analysis. The quantification method is also applied to pre- and postoperative scans of cataract patients. Here, we observe a higher variation between the measurements, which can be explained by the greater variation in scan quality. Statistical tests of both the healthy subjects and cataract patients show that our method is able to di↵erentiate subjects based on the extracted microvascular features.
Original languageEnglish
Title of host publicationMedical Image Understanding and Analysis
PublisherSpringer
Publication date2019
Pages257-269
ISBN (Print)978-3-030-39342-7
DOIs
Publication statusPublished - 2019
Event23rd Conference on Medical Image Understanding and Analysis - University of Liverpool, Liverpool, United Kingdom
Duration: 24 Jul 201926 Jul 2019
https://miua2019.com/

Conference

Conference23rd Conference on Medical Image Understanding and Analysis
LocationUniversity of Liverpool
CountryUnited Kingdom
CityLiverpool
Period24/07/201926/07/2019
Internet address
SeriesCommunications in Computer and Information Science
Volume1065
ISSN1865-0929

Keywords

  • OCTA
  • Dictionary-based segmentation
  • Quantification

Cite this

Engberg, A. M. E., Erichsen, J. H., Sander, B., Kessel, L., Dahl, A. B., & Dahl, V. A. (2019). Automated Quantification of Retinal Microvasculature from OCT Angiography using Dictionary-Based Vessel Segmentation. In Medical Image Understanding and Analysis (pp. 257-269). Springer. Communications in Computer and Information Science, Vol.. 1065 https://doi.org/10.1007/978-3-030-39343-4_22