This report describes and evaluates the steps needed to perform modern model-based interpretation of the corpus callosum in MRI. The process is discussed from the initial landmark-free contours to full-fledged statistical models based on the Active Appearance Models framework. Topics treated include landmark placement, background modelling and multi-resolution analysis. Preliminary quantitative and qualitative validation in a cross-sectional study show that fully automated analysis and segmentation of the corpus callosum are feasible.
| Publication status | Published - 2003 |
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