Augmenting engineered T-cell strategies in solid cancers through epigenetic priming

Aaraby Y. Nielsen, Maria Ormhøj, Sofie Traynor, Morten F. Gjerstorff*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

T-cell receptor (TCR)- and chimeric antigen receptor (CAR)-based adoptive cell transfer (ACT) has shown promising results in hematological malignancies, but remains immature in solid cancers. The challenges associated with identification of tumor-specific targets, the heterogenic antigen expression, limited T-cell trafficking to tumor sites and the hostile tumor microenvironment (TME), are all factors contributing to the limited efficacy of ACT therapies against solid tumors. Epigenetic priming of tumor cells and the microenvironment may be a way of overcoming these obstacles and improving the clinical efficacy of adoptive T-cell therapies in the future. Here, we review the current literature and suggest combining epigenetic modulators and ACT strategies as a way of augmenting the efficacy of TCR- and CAR-engineered T cells against solid tumors.
Original languageEnglish
JournalCancer Immunology, Immunotherapy
Volume69
Pages (from-to)2169–2178
ISSN0340-7004
DOIs
Publication statusPublished - 2020

Keywords

  • Cancer immunotherapy
  • Genetically modifed T cells
  • Solid tumors
  • Epigenetic drugs
  • Cancer/testis antigens
  • Combination therapy

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