Attenuation of beta and gamma oscillations in schizophrenia spectrum patients following hand posture perturbation

Sidse M. Arnfred, Morten Mørup, Jørgen Thalbitzer, Lennart Jansson, Josef Parnas

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Several electroencephalographic (EEG) studies in schizophrenia report that the patients have reduced evoked gamma activity following visual and auditory stimulation. Somatosensory gamma activity has not previously been examined. It has been suggested that a dysfunction basic to schizophrenia spectrum traits would involve proprioceptive information processing and this has recently been supported by the finding of diminished latency of early proprioceptive evoked potentials in a sample of chronic schizophrenia patients. The proprioceptive stimulus used previously, and presently, consisted of an abrupt increase of weight on a hand-held load. Eighteen first-time admitted schizophrenia spectrum patients and 18 healthy matched comparison subjects were included. Proprioceptive evoked potentials were recorded as 64-channels EEG for 120 trials in two runs differing in sequence. Contra-lateral evoked beta (latency 90ms, frequency 21Hz) and gamma (latency 70ms, frequency 32Hz) oscillations were attenuated in the patient group. The healthy comparison subjects had increased gamma amplitude in the left hemisphere in the regular sequence, a phenomenon not seen in the patients. The deviant findings were unexpectedly more circumscribed in the schizophrenia than in the schizotypal personality disorder (SPD) patients. Future studies should include several concurrent psychophysiological measures.
    Original languageEnglish
    JournalPsychiatry Research
    Volume185
    Issue number1-2
    Pages (from-to)215-224
    ISSN0165-1781
    DOIs
    Publication statusPublished - 2011

    Keywords

    • Schizophrenia
    • Gamma band activity
    • Somatosensory information processing
    • Beta oscillations
    • Schizotypal personality disorder
    • Proprioception
    • Matrix analysis

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