Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy.

Gertrud Laura Sørensen; Stine Knudsen; Eva Rosa Petersen; Jacob Kempfner; Steen Gammeltoft; Helge Bjarup Dissing Sørensen; Poul Jennum

doi:10.5665/sleep.2308

Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy.

Gertrud Laura Sørensen
, Stine Knudsen
, Eva Rosa Petersen
, Jacob Kempfner
, Steen Gammeltoft
, Helge Bjarup Dissing Sørensen
, Poul Jennum

Copenhagen University Hospital Herlev and Gentofte

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Our results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest. CITATION: Sorensen GL; Knudsen S; Petersen ER; Kempfner J; Gammeltoft S; Sorensen HBD; Jennum P. Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy. SLEEP 2013;36(1):91-98.

Original language	English
Journal	Sleep
Volume	36
Issue number	1
Pages (from-to)	91-98
ISSN	0161-8105
DOIs	https://doi.org/10.5665/sleep.2308
Publication status	Published - 2013

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@article{d0cc2e341487448e84bd50a6e2ccd94e,

title = "Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy.",

abstract = "Our results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest. CITATION: Sorensen GL; Knudsen S; Petersen ER; Kempfner J; Gammeltoft S; Sorensen HBD; Jennum P. Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy. SLEEP 2013;36(1):91-98.",

author = "S{\o}rensen, \{Gertrud Laura\} and Stine Knudsen and Petersen, \{Eva Rosa\} and Jacob Kempfner and Steen Gammeltoft and S{\o}rensen, \{Helge Bjarup Dissing\} and Poul Jennum",

year = "2013",

doi = "10.5665/sleep.2308",

language = "English",

volume = "36",

pages = "91--98",

journal = "Sleep",

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publisher = "Oxford University Press",

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TY - JOUR

T1 - Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy.

AU - Sørensen, Gertrud Laura

AU - Knudsen, Stine

AU - Petersen, Eva Rosa

AU - Kempfner, Jacob

AU - Gammeltoft, Steen

AU - Sørensen, Helge Bjarup Dissing

AU - Jennum, Poul

PY - 2013

Y1 - 2013

N2 - Our results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest. CITATION: Sorensen GL; Knudsen S; Petersen ER; Kempfner J; Gammeltoft S; Sorensen HBD; Jennum P. Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy. SLEEP 2013;36(1):91-98.

AB - Our results show that autonomic dysfunction is part of the narcoleptic phenotype, and that hypocretin-1 deficiency is the primary predictor of this dysfunction. This finding suggests that the hypocretin system participates in the modulation of cardiovascular function at rest. CITATION: Sorensen GL; Knudsen S; Petersen ER; Kempfner J; Gammeltoft S; Sorensen HBD; Jennum P. Attenuated heart rate response is associated with hypocretin deficiency in patients with narcolepsy. SLEEP 2013;36(1):91-98.

U2 - 10.5665/sleep.2308

DO - 10.5665/sleep.2308

M3 - Journal article

C2 - 23288975

SN - 0161-8105

VL - 36

SP - 91

EP - 98

JO - Sleep

JF - Sleep

IS - 1

ER -

Attenuated Heart Rate Response is Associated with Hypocretin Deficiency in Patients with Narcolepsy.

Abstract

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