Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species

Petur W. Dalsgaard; Bent O. Petersen; Jens Ø. Duus; Christian Zidorn; Jens Christian Frisvad; Carsten Christophersen; Thomas Ostenfeld Larsen

doi:10.3390/metabo2010214

Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species

Petur W. Dalsgaard, Bent O. Petersen, Jens Ø. Duus, Christian Zidorn, Jens Christian Frisvad, Carsten Christophersen, Thomas Ostenfeld Larsen

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Abstract

Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.

Original language	English
Journal	Metabolites
Volume	2
Pages (from-to)	214-220
ISSN	2218-1989
DOIs	https://doi.org/10.3390/metabo2010214
Publication status	Published - 2012

Keywords

Penicillium ribeum
atlantinone A
andrastin
psychrotolerant
cheese associated fungi

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10.3390/metabo2010214

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title = "Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species",

abstract = "Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.",

keywords = "Penicillium ribeum, atlantinone A, andrastin, psychrotolerant, cheese associated fungi",

author = "Dalsgaard, {Petur W.} and Petersen, {Bent O.} and Duus, {Jens {\O}.} and Christian Zidorn and Frisvad, {Jens Christian} and Carsten Christophersen and Larsen, {Thomas Ostenfeld}",

year = "2012",

doi = "10.3390/metabo2010214",

language = "English",

volume = "2",

pages = "214--220",

journal = "Metabolites",

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T1 - Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species

AU - Dalsgaard, Petur W.

AU - Petersen, Bent O.

AU - Duus, Jens Ø.

AU - Zidorn, Christian

AU - Frisvad, Jens Christian

AU - Christophersen, Carsten

AU - Larsen, Thomas Ostenfeld

PY - 2012

Y1 - 2012

N2 - Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.

AB - Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.

KW - Penicillium ribeum

KW - atlantinone A

KW - andrastin

KW - psychrotolerant

KW - cheese associated fungi

U2 - 10.3390/metabo2010214

DO - 10.3390/metabo2010214

M3 - Journal article

C2 - 24957375

SN - 2218-1989

VL - 2

SP - 214

EP - 220

JO - Metabolites

JF - Metabolites

ER -

Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species

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