Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species

Petur W. Dalsgaard, Bent O. Petersen, Jens Ø. Duus, Christian Zidorn, Jens Christian Frisvad, Carsten Christophersen, Thomas Ostenfeld Larsen

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    Abstract

    Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
    Original languageEnglish
    JournalMetabolites
    Volume2
    Pages (from-to)214-220
    ISSN2218-1989
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Penicillium ribeum
    • atlantinone A
    • andrastin
    • psychrotolerant
    • cheese associated fungi

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