Atlantinone A has been isolated from the psychrotolerant fungus Penicillium ribeum. The exact structure of the compound was confirmed by mass spectrometric and 1- and 2D NMR experiments. Atlantinone A was originally only produced upon chemical epigenetic manipulation of P. hirayamae, however in this study the compound was found to be produced at standard growth conditions by the following species; P. solitum, P. discolor, P. commune, P. caseifulvum, P. palitans, P. novae-zeelandiae and P. monticola. A biosynthetic pathway to atlantinone A starting from andrastin A is proposed.
- Penicillium ribeum
- atlantinone A
- cheese associated fungi
Dalsgaard, P. W., Petersen, B. O., Duus, J. Ø., Zidorn, C., Frisvad, J. C., Christophersen, C., & Larsen, T. O. (2012). Atlantinone A, a meroterpenoid produced by Penicillium ribeum and several cheese associated Penicillium species. Metabolites, 2, 214-220. https://doi.org/10.3390/metabo2010214