Atherosclerosis in low density lipoprotein receptor knockout mice fed cholesterol and soybean oil

Alicja Mortensen, P. Olsen, H. Frandsen

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

In order to study aortic atherosclerosis and atherosclerotic response to dietary cholesterol and soybean oil in homozygous LDLR-/- mice, the 16 weeks old animals were randomized in 4 groups either fed standard diet (no cholesterol added, group I, 12 male and 12 female), standard diet added 0.5% cholesterol (group II, 12 male and 12 female), standard diet added 10% soybean oil (group Iii, 7 male) or standard diet added 0.5% cholesterol and 10% soybean oil (group IV, 7 male) for 14 weeks. At termination, the plasma cholesterol of males was: 9.4 mmol/I +/- 0.3 (SD) (group I), 34.4 +/- 6.2 (group II), 9.9 +/- 0.07 (group III), 32.6 +/-0.1 (group IV), and of females 6.9 +/- 2.7 (group I) and 31.7 +/- 4.4 (group II). No apparent difference in plasma triglyceride levels was observed between the groups of either sexes. Aortic atherosclerosis (ratio intima/media) in males was 0.17 +/- 0.09 (SD) (group I), 0.96 +/- 0.32 (group II, p
Original languageEnglish
JournalNutrition Research
Volume19
Issue number4
Pages (from-to)613-622
ISSN0271-5317
Publication statusPublished - 1999

Keywords

  • soybean oil
  • LDLR-/-
  • LDLRKO
  • LDLR knockout mice
  • alpha-linolenic acid
  • blood lipids
  • atherosclerosis

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