Asymmetric Homer-Wadsworth-Emmons reactions between chiral phosphonate reagents and various meso-dialdehydes have been investigated. A mechanistic model useful for rationalizing the experimentally observed stereoselectivities is presented. Furthermore; strategies for applying these reactions to the stereocontrolled preparation of chiral heterocyclic building blocks have been developed.
|Journal||Phosphorus, Sulfur and Silicon and the Related Elements|
|Publication status||Published - 1999|
|Event||XIV International Conference on Phosphorus Chemistry - Cincinnati,OH, United States|
Duration: 12 Jul 1998 → 17 Jul 1998
Conference number: 14
|Conference||XIV International Conference on Phosphorus Chemistry|
|Period||12/07/1998 → 17/07/1998|
Rein, T., Vares, L., Kawasaki, I., Pedersen, T. M., Norrby, P-O., Brandt, P., & Tanner, D. A. (1999). Asymmetric Horner-Wadsworth-Emmons Reactions with meso-Dialdehydes: Scope, Mechanism, and Synthetic Applications. Phosphorus, Sulfur and Silicon and the Related Elements, 144-146, 169-172.