Asymmetric Horner-Wadsworth-Emmons Reactions with meso-Dialdehydes: Scope, Mechanism, and Synthetic Applications

Tobias Rein, Lauri Vares, Ikuo Kawasaki, Torben M. Pedersen, Per-Ola Norrby, Peter Brandt, David Ackland Tanner

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Asymmetric Homer-Wadsworth-Emmons reactions between chiral phosphonate reagents and various meso-dialdehydes have been investigated. A mechanistic model useful for rationalizing the experimentally observed stereoselectivities is presented. Furthermore; strategies for applying these reactions to the stereocontrolled preparation of chiral heterocyclic building blocks have been developed.
    Original languageEnglish
    JournalPhosphorus, Sulfur and Silicon and the Related Elements
    Volume144-146
    Pages (from-to)169-172
    ISSN1042-6507
    Publication statusPublished - 1999
    EventXIV International Conference on Phosphorus Chemistry - Cincinnati,OH, United States
    Duration: 12 Jul 199817 Jul 1998
    Conference number: 14

    Conference

    ConferenceXIV International Conference on Phosphorus Chemistry
    Number14
    CountryUnited States
    CityCincinnati,OH
    Period12/07/199817/07/1998

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