Associations Between the Severity of Obsessive-Compulsive Disorder and Vocal Features in Children and Adolescents: Protocol for a Statistical and Machine Learning Analysis

Line Katrine Harder Clemmensen, Nicole Nadine Lønfeldt, Sneha Das, Nicklas Leander Lund, Valdemar Funch Uhre, Anna-Rosa Cecilie Mora-Jensen, Linea Pretzmann, Camilla Funch Uhre, Melanie Ritter, Nicoline Løcke Jepsen Korsbjerg, Julie Hagstrøm, Christine Lykke Thoustrup, Iben Thiemer Clemmesen, Kersten Jessica Plessen, Anne Katrine Pagsberg

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Abstract

BACKGROUND: Artificial intelligence tools have the potential to objectively identify youth in need of mental health care. Speech signals have shown promise as a source for predicting various psychiatric conditions and transdiagnostic symptoms.

OBJECTIVE: We designed a study testing the association between obsessive-compulsive disorder (OCD) diagnosis and symptom severity on vocal features in children and adolescents. Here, we present an analysis plan and statistical report for the study to document our a priori hypotheses and increase the robustness of the findings of our planned study.

METHODS: Audio recordings of clinical interviews of 47 children and adolescents with OCD and 17 children and adolescents without a psychiatric diagnosis will be analyzed. Youths were between 8 and 17 years old. We will test the effect of OCD diagnosis on computationally derived scores of vocal activation using ANOVA. To test the effect of OCD severity classifications on the same computationally derived vocal scores, we will perform a logistic regression. Finally, we will attempt to create an improved indicator of OCD severity by refining the model with more relevant labels. Models will be adjusted for age and gender. Model validation strategies are outlined.

RESULTS: Simulated results are presented. The actual results using real data will be presented in future publications.

CONCLUSIONS: A major strength of this study is that we will include age and gender in our models to increase classification accuracy. A major challenge is the suboptimal quality of the audio recordings, which are representative of in-the-wild data and a large body of recordings collected during other clinical trials. This preregistered analysis plan and statistical report will increase the validity of the interpretations of the upcoming results.

INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/39613.

Original languageEnglish
Article numbere39613
JournalJMIR Research Protocols
Volume11
Issue number10
Number of pages12
ISSN1929-0748
DOIs
Publication statusPublished - 28 Oct 2022

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