TY - JOUR
T1 - Associations between Red Meat and Risks for Colon and Rectal Cancer Depend on the Type of Red Meat Consumed
AU - Egeberg, Rikke
AU - Olsen, Anja
AU - Christensen, Jane Nyrup
AU - Halkjaer, Jytte
AU - Jakobsen, Marianne Uhre
AU - Overvad, Kim
AU - Tjonneland, Anne
PY - 2013
Y1 - 2013
N2 - Cancer prevention guidelines recommend limiting intake of red meat and avoiding processed meat; however, few studies have been conducted on the effects of specific red meat subtypes on colon cancer or rectal cancer risk. The study aim was to evaluate associations between intake of red meat and its subtypes, processed meat, fish, and poultry and risk for colon cancer or rectal cancer in the Danish Diet, Cancer and Health cohort study. We also evaluated whether fish or poultry should replace red meat intake to prevent colon cancer or rectal cancer. During follow-up (13.4 y), 644 cases of colon cancer and 345 cases of rectal cancer occurred among 53,988 participants. Cox proportional hazards models were used to compute incidence rate ratio (IRRs) and 95% Cls. No associations were found between intake of red meat, processed meat, fish, or poultry and risk for colon cancer or rectal cancer. The risk associated with specific red meat subtypes depended on the animal of origin and cancer subsite; thus, the risk for colon cancer was significantly elevated for higher intake of lamb [IRRper (5g/d) = 1.07 (95% Cl: 1.02-1.13)], whereas the risk for rectal cancer was elevated for higher intake of pork [IRRper (25g/d) = 1.18 (95% Cl: 1.02-1.36)]. Substitution of fish for red meat was associated with a significantly lower risk for colon cancer [IRRper (25g/d) = 0.89 (95% Cl: 0.80-0.99)] but not rectal cancer. Substitution of poultry for red meat did not reduce either risk. This study suggests that the risks for colon cancer and potentially for rectal cancer differ according to the specific red meat subtype consumed. J. Nutr. 143: 464-472, 2013.
AB - Cancer prevention guidelines recommend limiting intake of red meat and avoiding processed meat; however, few studies have been conducted on the effects of specific red meat subtypes on colon cancer or rectal cancer risk. The study aim was to evaluate associations between intake of red meat and its subtypes, processed meat, fish, and poultry and risk for colon cancer or rectal cancer in the Danish Diet, Cancer and Health cohort study. We also evaluated whether fish or poultry should replace red meat intake to prevent colon cancer or rectal cancer. During follow-up (13.4 y), 644 cases of colon cancer and 345 cases of rectal cancer occurred among 53,988 participants. Cox proportional hazards models were used to compute incidence rate ratio (IRRs) and 95% Cls. No associations were found between intake of red meat, processed meat, fish, or poultry and risk for colon cancer or rectal cancer. The risk associated with specific red meat subtypes depended on the animal of origin and cancer subsite; thus, the risk for colon cancer was significantly elevated for higher intake of lamb [IRRper (5g/d) = 1.07 (95% Cl: 1.02-1.13)], whereas the risk for rectal cancer was elevated for higher intake of pork [IRRper (25g/d) = 1.18 (95% Cl: 1.02-1.36)]. Substitution of fish for red meat was associated with a significantly lower risk for colon cancer [IRRper (25g/d) = 0.89 (95% Cl: 0.80-0.99)] but not rectal cancer. Substitution of poultry for red meat did not reduce either risk. This study suggests that the risks for colon cancer and potentially for rectal cancer differ according to the specific red meat subtype consumed. J. Nutr. 143: 464-472, 2013.
U2 - 10.3945/jn.112.168799
DO - 10.3945/jn.112.168799
M3 - Journal article
SN - 0022-3166
VL - 143
SP - 464
EP - 472
JO - Journal of Nutrition
JF - Journal of Nutrition
IS - 4
ER -