Associations between multiple indoor environmental factors and clinically confirmed allergic disease in early childhood

Mette Buhl Callesen, Gabriel Bekö, Charles J. Weschler, T. Sigsgaard, T. Jensen, G. Clausen, J. Toftum, L. Norberg, A. Hoest

Research output: Contribution to journalConference abstract in journalResearchpeer-review

Abstract

Background: Previous studies, mainly questionnaires have reported associations between some indoor environmental factors and allergic diseases. Our aim was to investigate the possible association between objectively assessed indoor environmental factors and clinically confirmed asthma, rhinoconjunctivitis and atopic dermatitis.
Method: A crosssectional case-cohort study (n = 500) based on 2835 children, aged 3–5 years, responding to a questionnaire, consisted of 300 subjects randomly selected and 200 cases with at least two parentally reported doctor diagnosed allergic diseases (asthma, allergic rhinoconjunctivitis or atopic dermatitis). The same physician conducted a clinical examination of all the 500 children including structured interview on allergic heredity, clinical and medical history. Specific s-IgE against inhalant and food allergens was determined. The homes were investigated by inspectors assessing air change rates, relative humidity, temperature, CO2, and dust samples were collected for analyses of indoor allergens, phthalates, nicotine and polyaromatic hydrocarbons. The diagnosis of allergic disease was based on internationally accepted criteria.
Result: In the base group (n = 300) asthma was clinically diagnosed in 5.1%, rhinoconjunctivitis in 5.1% and atopic dermatitis in 11.0%. Air change rates were below the recommended 0.5 in 56% of all the homes. Air change rates were higher among children asthma/rhinoconjunctivitis (P < 0.05). Stratified analyses showed lower air change rates (P < 0.05) in sensitized
children with asthma. Concentrations of nicotine and house dust mite allergens were higher (P < 0.05) and cat allergens lower (P < 0.05) in the asthma group. When the diagnosis of allergic disease was based solely on questionnaire data no significant associations between environmental factors and allergic disease were found.
Conclusion: Air change rates were insufficient in the majority of the homes, and low rates were associated with higher concentrations of HDM allergens and sensitization in children with asthma. Asthma was associated with higher levels of nicotine and phthalates in dust. Pet keeping history proved an active avoidance behavior against cats. The lower levels of cat allergens
among asthmatics may reflect avoidance behavior agains ‘visible’ allergen sources (cat) but not to ‘invisible’ allergens (HDM). Questionnaire studies are inappropriate for evaluation for analysis of interaction between indoor.
Original languageEnglish
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume67
Issue numberIssue Supplement s96
Pages (from-to)630
ISSN0105-4538
Publication statusPublished - 2012
EventXXXI Congress of the European Academy of Allergy and Clinical Immunology - Geneva, Switzerland
Duration: 16 Jun 201220 Jun 2012
Conference number: 31

Conference

ConferenceXXXI Congress of the European Academy of Allergy and Clinical Immunology
Number31
CountrySwitzerland
CityGeneva
Period16/06/201220/06/2012

Cite this

@article{298940c2fa4f48aabf4ddc3fdc9a268d,
title = "Associations between multiple indoor environmental factors and clinically confirmed allergic disease in early childhood",
abstract = "Background: Previous studies, mainly questionnaires have reported associations between some indoor environmental factors and allergic diseases. Our aim was to investigate the possible association between objectively assessed indoor environmental factors and clinically confirmed asthma, rhinoconjunctivitis and atopic dermatitis.Method: A crosssectional case-cohort study (n = 500) based on 2835 children, aged 3–5 years, responding to a questionnaire, consisted of 300 subjects randomly selected and 200 cases with at least two parentally reported doctor diagnosed allergic diseases (asthma, allergic rhinoconjunctivitis or atopic dermatitis). The same physician conducted a clinical examination of all the 500 children including structured interview on allergic heredity, clinical and medical history. Specific s-IgE against inhalant and food allergens was determined. The homes were investigated by inspectors assessing air change rates, relative humidity, temperature, CO2, and dust samples were collected for analyses of indoor allergens, phthalates, nicotine and polyaromatic hydrocarbons. The diagnosis of allergic disease was based on internationally accepted criteria.Result: In the base group (n = 300) asthma was clinically diagnosed in 5.1{\%}, rhinoconjunctivitis in 5.1{\%} and atopic dermatitis in 11.0{\%}. Air change rates were below the recommended 0.5 in 56{\%} of all the homes. Air change rates were higher among children asthma/rhinoconjunctivitis (P < 0.05). Stratified analyses showed lower air change rates (P < 0.05) in sensitizedchildren with asthma. Concentrations of nicotine and house dust mite allergens were higher (P < 0.05) and cat allergens lower (P < 0.05) in the asthma group. When the diagnosis of allergic disease was based solely on questionnaire data no significant associations between environmental factors and allergic disease were found.Conclusion: Air change rates were insufficient in the majority of the homes, and low rates were associated with higher concentrations of HDM allergens and sensitization in children with asthma. Asthma was associated with higher levels of nicotine and phthalates in dust. Pet keeping history proved an active avoidance behavior against cats. The lower levels of cat allergensamong asthmatics may reflect avoidance behavior agains ‘visible’ allergen sources (cat) but not to ‘invisible’ allergens (HDM). Questionnaire studies are inappropriate for evaluation for analysis of interaction between indoor.",
author = "Callesen, {Mette Buhl} and Gabriel Bek{\"o} and Weschler, {Charles J.} and T. Sigsgaard and T. Jensen and G. Clausen and J. Toftum and L. Norberg and A. Hoest",
year = "2012",
language = "English",
volume = "67",
pages = "630",
journal = "Allergy: European Journal of Allergy and Clinical Immunology",
issn = "0105-4538",
publisher = "Wiley Online",
number = "Issue Supplement s96",

}

Associations between multiple indoor environmental factors and clinically confirmed allergic disease in early childhood. / Callesen, Mette Buhl; Bekö, Gabriel; Weschler, Charles J.; Sigsgaard, T.; Jensen, T.; Clausen, G.; Toftum, J.; Norberg, L.; Hoest, A.

In: Allergy: European Journal of Allergy and Clinical Immunology, Vol. 67, No. Issue Supplement s96, 2012, p. 630.

Research output: Contribution to journalConference abstract in journalResearchpeer-review

TY - ABST

T1 - Associations between multiple indoor environmental factors and clinically confirmed allergic disease in early childhood

AU - Callesen, Mette Buhl

AU - Bekö, Gabriel

AU - Weschler, Charles J.

AU - Sigsgaard, T.

AU - Jensen, T.

AU - Clausen, G.

AU - Toftum, J.

AU - Norberg, L.

AU - Hoest, A.

PY - 2012

Y1 - 2012

N2 - Background: Previous studies, mainly questionnaires have reported associations between some indoor environmental factors and allergic diseases. Our aim was to investigate the possible association between objectively assessed indoor environmental factors and clinically confirmed asthma, rhinoconjunctivitis and atopic dermatitis.Method: A crosssectional case-cohort study (n = 500) based on 2835 children, aged 3–5 years, responding to a questionnaire, consisted of 300 subjects randomly selected and 200 cases with at least two parentally reported doctor diagnosed allergic diseases (asthma, allergic rhinoconjunctivitis or atopic dermatitis). The same physician conducted a clinical examination of all the 500 children including structured interview on allergic heredity, clinical and medical history. Specific s-IgE against inhalant and food allergens was determined. The homes were investigated by inspectors assessing air change rates, relative humidity, temperature, CO2, and dust samples were collected for analyses of indoor allergens, phthalates, nicotine and polyaromatic hydrocarbons. The diagnosis of allergic disease was based on internationally accepted criteria.Result: In the base group (n = 300) asthma was clinically diagnosed in 5.1%, rhinoconjunctivitis in 5.1% and atopic dermatitis in 11.0%. Air change rates were below the recommended 0.5 in 56% of all the homes. Air change rates were higher among children asthma/rhinoconjunctivitis (P < 0.05). Stratified analyses showed lower air change rates (P < 0.05) in sensitizedchildren with asthma. Concentrations of nicotine and house dust mite allergens were higher (P < 0.05) and cat allergens lower (P < 0.05) in the asthma group. When the diagnosis of allergic disease was based solely on questionnaire data no significant associations between environmental factors and allergic disease were found.Conclusion: Air change rates were insufficient in the majority of the homes, and low rates were associated with higher concentrations of HDM allergens and sensitization in children with asthma. Asthma was associated with higher levels of nicotine and phthalates in dust. Pet keeping history proved an active avoidance behavior against cats. The lower levels of cat allergensamong asthmatics may reflect avoidance behavior agains ‘visible’ allergen sources (cat) but not to ‘invisible’ allergens (HDM). Questionnaire studies are inappropriate for evaluation for analysis of interaction between indoor.

AB - Background: Previous studies, mainly questionnaires have reported associations between some indoor environmental factors and allergic diseases. Our aim was to investigate the possible association between objectively assessed indoor environmental factors and clinically confirmed asthma, rhinoconjunctivitis and atopic dermatitis.Method: A crosssectional case-cohort study (n = 500) based on 2835 children, aged 3–5 years, responding to a questionnaire, consisted of 300 subjects randomly selected and 200 cases with at least two parentally reported doctor diagnosed allergic diseases (asthma, allergic rhinoconjunctivitis or atopic dermatitis). The same physician conducted a clinical examination of all the 500 children including structured interview on allergic heredity, clinical and medical history. Specific s-IgE against inhalant and food allergens was determined. The homes were investigated by inspectors assessing air change rates, relative humidity, temperature, CO2, and dust samples were collected for analyses of indoor allergens, phthalates, nicotine and polyaromatic hydrocarbons. The diagnosis of allergic disease was based on internationally accepted criteria.Result: In the base group (n = 300) asthma was clinically diagnosed in 5.1%, rhinoconjunctivitis in 5.1% and atopic dermatitis in 11.0%. Air change rates were below the recommended 0.5 in 56% of all the homes. Air change rates were higher among children asthma/rhinoconjunctivitis (P < 0.05). Stratified analyses showed lower air change rates (P < 0.05) in sensitizedchildren with asthma. Concentrations of nicotine and house dust mite allergens were higher (P < 0.05) and cat allergens lower (P < 0.05) in the asthma group. When the diagnosis of allergic disease was based solely on questionnaire data no significant associations between environmental factors and allergic disease were found.Conclusion: Air change rates were insufficient in the majority of the homes, and low rates were associated with higher concentrations of HDM allergens and sensitization in children with asthma. Asthma was associated with higher levels of nicotine and phthalates in dust. Pet keeping history proved an active avoidance behavior against cats. The lower levels of cat allergensamong asthmatics may reflect avoidance behavior agains ‘visible’ allergen sources (cat) but not to ‘invisible’ allergens (HDM). Questionnaire studies are inappropriate for evaluation for analysis of interaction between indoor.

M3 - Conference abstract in journal

VL - 67

SP - 630

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

SN - 0105-4538

IS - Issue Supplement s96

ER -