Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity

Sofus C. Larsen; Lars Angquist; Charles Laurin; Camilla S. Morgen; Marianne Uhre Jakobsen; Lavinia Paternoster; George Davey Smith; Sjurdur F. Olsen; Thorkild I. A. Sorensen; Ellen A. Nohr; Alberto G Passi

doi:10.1371/journal.pone.0150105

Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity

Sofus C. Larsen
, Lars Angquist
, Charles Laurin
, Camilla S. Morgen
, Marianne Uhre Jakobsen
, Lavinia Paternoster
, George Davey Smith
, Sjurdur F. Olsen
, Thorkild I. A. Sorensen
, Ellen A. Nohr
, Alberto G Passi (Editor)

Copenhagen University Hospital Frederiksberg and Bispebjerg
University of Bristol
Aarhus University
Statens Serum Institut
University of Southern Denmark

Research output: Contribution to journal › Journal article › Research › peer-review

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Abstract

BackgroundStudies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup.ObjectiveTo examine the association between fish consumption and GWG, and whether this relationship is dependent on molecular genetic predisposition to obesity.DesignA nested case-cohort study based on the Danish National Birth Cohort (DNBC) sampling the most obese women (n = 990) and a random sample of the remaining participants (n = 1,128). Replication of statistically significant findings was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 4,841). We included 32 body mass index (BMI) associated single nucleotide polymorphisms (SNPs) and 5 SNPs found associated with GWG. BMI associated SNPs were combined in a genetic risk score (GRS). Associations between consumption of fish, GRS or individual variants and GWG were analysed, and interactions between fish and the GRS or individual variants were examined.ResultsIn the DNBC, each portion/week (150 g) of fatty fish was associated with a higher GWG of 0.58 kg (95% CI: 0.16, 0.99, P

Original language	English
Article number	e0150105
Journal	P L o S One
Volume	11
Issue number	3
Number of pages	16
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0150105
Publication status	Published - 2016
Externally published	Yes

Bibliographical note

© 2016 Larsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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Larsen, S. C., Angquist, L., Laurin, C., Morgen, C. S., Jakobsen, M. U., Paternoster, L., Smith, G. D., Olsen, S. F., Sorensen, T. I. A., Nohr, E. A., & Passi, A. G. (Ed.) (2016). Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity. P L o S One, 11(3), Article e0150105. https://doi.org/10.1371/journal.pone.0150105

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title = "Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity",

abstract = "BackgroundStudies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup.ObjectiveTo examine the association between fish consumption and GWG, and whether this relationship is dependent on molecular genetic predisposition to obesity.DesignA nested case-cohort study based on the Danish National Birth Cohort (DNBC) sampling the most obese women (n = 990) and a random sample of the remaining participants (n = 1,128). Replication of statistically significant findings was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 4,841). We included 32 body mass index (BMI) associated single nucleotide polymorphisms (SNPs) and 5 SNPs found associated with GWG. BMI associated SNPs were combined in a genetic risk score (GRS). Associations between consumption of fish, GRS or individual variants and GWG were analysed, and interactions between fish and the GRS or individual variants were examined.ResultsIn the DNBC, each portion/week (150 g) of fatty fish was associated with a higher GWG of 0.58 kg (95\% CI: 0.16, 0.99, P",

author = "Larsen, \{Sofus C.\} and Lars Angquist and Charles Laurin and Morgen, \{Camilla S.\} and Jakobsen, \{Marianne Uhre\} and Lavinia Paternoster and Smith, \{George Davey\} and Olsen, \{Sjurdur F.\} and Sorensen, \{Thorkild I. A.\} and Nohr, \{Ellen A.\} and Passi, \{Alberto G\}",

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year = "2016",

doi = "10.1371/journal.pone.0150105",

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T2 - Influence of Molecular Genetic Predisposition to Obesity

AU - Larsen, Sofus C.

AU - Angquist, Lars

AU - Laurin, Charles

AU - Morgen, Camilla S.

AU - Jakobsen, Marianne Uhre

AU - Paternoster, Lavinia

AU - Smith, George Davey

AU - Olsen, Sjurdur F.

AU - Sorensen, Thorkild I. A.

AU - Nohr, Ellen A.

A2 - Passi, Alberto G

N1 - © 2016 Larsen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2016

Y1 - 2016

N2 - BackgroundStudies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup.ObjectiveTo examine the association between fish consumption and GWG, and whether this relationship is dependent on molecular genetic predisposition to obesity.DesignA nested case-cohort study based on the Danish National Birth Cohort (DNBC) sampling the most obese women (n = 990) and a random sample of the remaining participants (n = 1,128). Replication of statistically significant findings was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 4,841). We included 32 body mass index (BMI) associated single nucleotide polymorphisms (SNPs) and 5 SNPs found associated with GWG. BMI associated SNPs were combined in a genetic risk score (GRS). Associations between consumption of fish, GRS or individual variants and GWG were analysed, and interactions between fish and the GRS or individual variants were examined.ResultsIn the DNBC, each portion/week (150 g) of fatty fish was associated with a higher GWG of 0.58 kg (95% CI: 0.16, 0.99, P

AB - BackgroundStudies suggest that fish consumption can restrict weight gain. However, little is known about how fish consumption affects gestational weight gain (GWG), and whether this relationship depends on genetic makeup.ObjectiveTo examine the association between fish consumption and GWG, and whether this relationship is dependent on molecular genetic predisposition to obesity.DesignA nested case-cohort study based on the Danish National Birth Cohort (DNBC) sampling the most obese women (n = 990) and a random sample of the remaining participants (n = 1,128). Replication of statistically significant findings was attempted in the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 4,841). We included 32 body mass index (BMI) associated single nucleotide polymorphisms (SNPs) and 5 SNPs found associated with GWG. BMI associated SNPs were combined in a genetic risk score (GRS). Associations between consumption of fish, GRS or individual variants and GWG were analysed, and interactions between fish and the GRS or individual variants were examined.ResultsIn the DNBC, each portion/week (150 g) of fatty fish was associated with a higher GWG of 0.58 kg (95% CI: 0.16, 0.99, P

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DO - 10.1371/journal.pone.0150105

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SN - 1932-6203

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JO - P L o S One

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Association between Maternal Fish Consumption and Gestational Weight Gain: Influence of Molecular Genetic Predisposition to Obesity

Abstract

Bibliographical note

UN SDGs

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