Assessment of modified gold surfaced titanium implants on skeletal fixation

Kasra Zainali, Gorm Danscher, Thomas Jakobsen, Jorgen Baas, Per Møller, Joan E. Bechtold, Kjeld Soballe

    Research output: Contribution to journalJournal articleResearchpeer-review


    Noncemented implants are the primary choice for younger patients undergoing total hip replacements. However, the major concern in this group of patients regarding revision is the concern from wear particles, periimplant inflammation, and subsequently aseptic implant loosening. Macrophages have been shown to liberate gold ions through the process termed dissolucytosis. Furthermore, gold ions are known to act in an anti-inflammatory manner by inhibiting cellular NF-κB-DNA binding. The present study investigated whether partial coating of titanium implants could augment early osseointegration and increase mechanical fixation. Cylindrical porous coated Ti-6Al4V implants partially coated with metallic gold were inserted in the proximal region of the humerus in ten canines and control implants without gold were inserted in contralateral humerus. Observation time was 4 weeks. Biomechanical push out tests and stereological histomorphometrical analyses showed no statistically significant differences in the two groups. The unchanged parameters are considered an improvement of the coating properties, as a previous complete gold-coated implant showed inferior mechanical fixation and reduced osseointegration compared to control titanium implants in a similar model. Since sufficient early mechanical fixation is achieved with this new coating, it is reasonable to investigate the implant further in long-term studies. © 2012 Wiley Periodicals, Inc.
    Original languageEnglish
    JournalJournal of Biomedical Materials Research. Part A
    Volume101 A
    Issue number1
    Pages (from-to)195-202
    Publication statusPublished - 2013


    • Arthroplasty
    • Biomechanics
    • Coatings
    • Fracture fixation
    • Gold
    • Implants (surgical)
    • Titanium
    • Gold coatings


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