Assessment of Model Predictive and Adaptive Glucose Control Strategies for People with Type 1 Diabetes

Dimitri Boiroux, Anne Katrine Duun-Henriksen, Signe Schmidt, Kirsten Nørgaard, Niels Kjølstad Poulsen, Henrik Madsen, John Bagterp Jørgensen

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Abstract

This paper addresses overnight blood glucose stabilization in people with type 1 diabetes using a Model Predictive Controller (MPC). We use a control strategy based on an adaptive ARMAX model in which we use a Recursive Extended Least Squares (RELS) method to estimate parameters of the stochastic part. We compare this model structure with an autoregressive integrated moving average with exogenous input (ARIMAX) structure, and with an autoregressive moving average with exogenous input (ARMAX) model, i.e. without an integrator. Additionally, safety layers improve the controller robustness and reduce the risk of hypoglycemia. We test our control strategies on a virtual clinic of 100 randomly generated patients with a representative inter-subject variability. This virtual clinic is based on the Hovorka model. We consider the case where only half of the meal bolus is administered at mealtime, and the case where the insulin sensitivity varies during the night. The simulation results demonstrate that the adaptive control strategy can reduce the risks of hypoglycemia and hyperglycemia during the night.
Original languageEnglish
Title of host publicationPreprints of the 19th World Congress The International Federation of Automatic Control (IFAC 2014)
Publication date2014
Pages231-236
Publication statusPublished - 2014
Event19th World Congress of the International Federation of Automatic Control (IFAC 2014) - Cape Town, South Africa
Duration: 24 Aug 201429 Aug 2014
http://www.ifac2014.org/

Conference

Conference19th World Congress of the International Federation of Automatic Control (IFAC 2014)
CountrySouth Africa
CityCape Town
Period24/08/201429/08/2014
OtherThe theme of the congress: “Promoting automatic control for the benefit of humankind”
Internet address

Cite this

Boiroux, D., Duun-Henriksen, A. K., Schmidt, S., Nørgaard, K., Poulsen, N. K., Madsen, H., & Jørgensen, J. B. (2014). Assessment of Model Predictive and Adaptive Glucose Control Strategies for People with Type 1 Diabetes. In Preprints of the 19th World Congress The International Federation of Automatic Control (IFAC 2014) (pp. 231-236)