Abstract
This paper addresses overnight blood glucose stabilization in people with type 1 diabetes using a Model Predictive Controller (MPC). We use a control strategy based on an adaptive ARMAX model in which we use a Recursive Extended Least Squares (RELS) method to estimate parameters of the stochastic part. We compare this model structure with an autoregressive integrated moving average with exogenous input (ARIMAX) structure, and with an autoregressive moving average with exogenous input (ARMAX) model, i.e. without an integrator. Additionally, safety layers improve the controller robustness and reduce the risk of hypoglycemia. We test our control strategies on a virtual clinic of 100 randomly generated patients with a representative inter-subject variability. This virtual clinic is based on the Hovorka model. We consider the case where only half of the meal bolus is administered at mealtime, and the case where the insulin sensitivity varies during the night. The simulation results demonstrate that the adaptive control strategy can reduce the risks of hypoglycemia and hyperglycemia during the night.
Original language | English |
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Title of host publication | Preprints of the 19th World Congress The International Federation of Automatic Control (IFAC 2014) |
Publication date | 2014 |
Pages | 231-236 |
Publication status | Published - 2014 |
Event | 19th World Congress of the International Federation of Automatic Control (IFAC 2014) - Cape Town, South Africa Duration: 24 Aug 2014 → 29 Aug 2014 http://www.ifac2014.org/ |
Conference
Conference | 19th World Congress of the International Federation of Automatic Control (IFAC 2014) |
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Country/Territory | South Africa |
City | Cape Town |
Period | 24/08/2014 → 29/08/2014 |
Other | The theme of the congress: “Promoting automatic control for the benefit of humankind” |
Internet address |