Assessment of a new model of glucagon action with glucagon receptor dynamics

Clara Furió-Novejarque; Ricardo Sanz; Asbjørn Thode Reenberg; Tobias K.S. Ritschel; Ajenthen G. Ranjan; Kirsten Nørgaard; Jose Luis Díez; John Bagterp Jørgensen; Jorge Bondia

doi:10.1016/j.ifacol.2022.09.169

Assessment of a new model of glucagon action with glucagon receptor dynamics

Clara Furió-Novejarque
, Ricardo Sanz
, Asbjørn Thode Reenberg
, Tobias K.S. Ritschel
, Ajenthen G. Ranjan
, Kirsten Nørgaard
, Jose Luis Díez
, John Bagterp Jørgensen
, Jorge Bondia^*

^*Corresponding author for this work

Polytechnic University of Valencia
Steno Diabetes Centre

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

150 Downloads (Orbit)

Abstract

In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

Original language	English
Title of host publication	Proceedings of 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022
Volume	55
Publisher	ScienceDirect
Publication date	2022
Edition	20
Pages	647-652
DOIs	https://doi.org/10.1016/j.ifacol.2022.09.169
Publication status	Published - 2022
Event	10th Vienna International Conference on Mathematical Modelling: MATHMOD 2022 - Vienna, Austria Duration: 27 Jul 2022 → 29 Jul 2022 Conference number: 10

Conference

Conference	10th Vienna International Conference on Mathematical Modelling
Number	10
Country/Territory	Austria
City	Vienna
Period	27/07/2022 → 29/07/2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Clinical data
Diabetes
Glucagon receptors
Parameter estimation
PK-PD model

Access to Document

10.1016/j.ifacol.2022.09.169Licence: CC BY-NC-ND

FulltextFinal published version, 554 KBLicence: CC BY-NC-ND

OpenUrl availability

Check availability in DTU Findit

Cite this

Furió-Novejarque, C., Sanz, R., Reenberg, A. T., Ritschel, T. K. S., Ranjan, A. G., Nørgaard, K., Díez, J. L., Jørgensen, J. B., & Bondia, J. (2022). Assessment of a new model of glucagon action with glucagon receptor dynamics. In Proceedings of 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022 (20 ed., Vol. 55, pp. 647-652). ScienceDirect. https://doi.org/10.1016/j.ifacol.2022.09.169

@inproceedings{94bbb04003fc43f9b3a957e6c974ae1c,

title = "Assessment of a new model of glucagon action with glucagon receptor dynamics",

abstract = "In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.",

keywords = "Clinical data, Diabetes, Glucagon receptors, Parameter estimation, PK-PD model",

author = "Clara Furi{\'o}-Novejarque and Ricardo Sanz and Reenberg, \{Asbj{\o}rn Thode\} and Ritschel, \{Tobias K.S.\} and Ranjan, \{Ajenthen G.\} and Kirsten N{\o}rgaard and D{\'i}ez, \{Jose Luis\} and J{\o}rgensen, \{John Bagterp\} and Jorge Bondia",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors.; 10th Vienna International Conference on Mathematical Modelling : MATHMOD 2022, MATHMOD ; Conference date: 27-07-2022 Through 29-07-2022",

year = "2022",

doi = "10.1016/j.ifacol.2022.09.169",

language = "English",

volume = "55",

pages = "647--652",

booktitle = "Proceedings of 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022",

publisher = "ScienceDirect",

edition = "20",

}

Furió-Novejarque, C, Sanz, R, Reenberg, AT, Ritschel, TKS, Ranjan, AG, Nørgaard, K, Díez, JL, Jørgensen, JB & Bondia, J 2022, Assessment of a new model of glucagon action with glucagon receptor dynamics. in Proceedings of 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022. 20 edn, vol. 55, ScienceDirect, pp. 647-652, 10th Vienna International Conference on Mathematical Modelling, Vienna, Austria, 27/07/2022. https://doi.org/10.1016/j.ifacol.2022.09.169

Assessment of a new model of glucagon action with glucagon receptor dynamics. / Furió-Novejarque, Clara; Sanz, Ricardo; Reenberg, Asbjørn Thode et al.
Proceedings of 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022. Vol. 55 20. ed. ScienceDirect, 2022. p. 647-652.

Research output: Chapter in Book/Report/Conference proceeding › Article in proceedings › Research › peer-review

TY - GEN

T1 - Assessment of a new model of glucagon action with glucagon receptor dynamics

AU - Furió-Novejarque, Clara

AU - Sanz, Ricardo

AU - Reenberg, Asbjørn Thode

AU - Ritschel, Tobias K.S.

AU - Ranjan, Ajenthen G.

AU - Nørgaard, Kirsten

AU - Díez, Jose Luis

AU - Jørgensen, John Bagterp

AU - Bondia, Jorge

N1 - Conference code: 10

PY - 2022

Y1 - 2022

N2 - In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

AB - In this work, a novel insulin-glucagon-glucose model is proposed, where the glucagon effect on the endogenous glucose production (EGP) is described by the dynamics of the glucagon receptors. In order to assess the quality of the model, its parameters are fitted in such a way that the influence of glucagon on EGP is isolated. Experimental data is used to validate the model structure and show that the receptor dynamics allow to explain some of the glucagon-related phenomena observed in the clinical data. This physiology-focused model will be useful in the development of artificial pancreas algorithms both for more realistic in silico validations and in the development of model-based control strategies.

KW - Clinical data

KW - Diabetes

KW - Glucagon receptors

KW - Parameter estimation

KW - PK-PD model

U2 - 10.1016/j.ifacol.2022.09.169

DO - 10.1016/j.ifacol.2022.09.169

M3 - Article in proceedings

AN - SCOPUS:85142216875

VL - 55

SP - 647

EP - 652

BT - Proceedings of 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022

PB - ScienceDirect

T2 - 10th Vienna International Conference on Mathematical Modelling

Y2 - 27 July 2022 through 29 July 2022

ER -

Assessment of a new model of glucagon action with glucagon receptor dynamics

Abstract

Conference

UN SDGs

Keywords

Access to Document

OpenUrl availability

Fingerprint

Cite this