Assembly and synthesis of the extracellular matrix in brown algae

Lisa Mazéas, Rina Yonamine, Tristan Barbeyron, Bernard Henrissat, Elodie Drula, Nicolas Terrapon, Chikako Nagasato, Cécile Hervé*

*Corresponding author for this work

Research output: Contribution to journalReviewpeer-review

36 Downloads (Pure)


In brown algae, the extracellular matrix (ECM) and its constitutive polymers play crucial roles in specialized functions, including algal growth and development. In this review we offer an integrative view of ECM construction in brown algae. We briefly report the chemical composition of its main constituents, and how these are interlinked in a structural model. We examine the ECM assembly at the tissue and cell level, with consideration on its structure in vivo and on the putative subcellular sites for the synthesis of its main constituents. We further discuss the biosynthetic pathways of two major polysaccharides, alginates and sulfated fucans, and the progress made beyond the candidate genes with the biochemical validation of encoded proteins. Key enzymes involved in the elongation of the glycan chains are still unknown and predictions have been made at the gene level. Here, we offer a re-examination of some glycosyltransferases and sulfotransferases from published genomes. Overall, our analysis suggests novel investigations to be performed at both the cellular and biochemical levels. First, to depict the location of polysaccharide structures in tissues. Secondly, to identify putative actors in the ECM synthesis to be functionally studied in the future.
Original languageEnglish
JournalSeminars in Cell and Developmental Biology
Pages (from-to)112-124
Number of pages13
Publication statusPublished - 2023


  • Extracellular matrix
  • Brown algae
  • Alginates
  • Fucans
  • Glycosyltransferases
  • Sulfotransferases


Dive into the research topics of 'Assembly and synthesis of the extracellular matrix in brown algae'. Together they form a unique fingerprint.

Cite this