Aspiperidine oxide, a piperidine N-oxide from the filamentous fungus Aspergillus indologenus

Lene Maj Petersen, Sara Kildgaard, Marcel Jaspars, Thomas Ostenfeld Larsen

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    A novel secondary metabolite, aspiperidine oxide, was isolated from the filamentous fungus, Aspergillus indologenus. The structure of aspiperidine oxide was determined from extensive 1D and 2D NMR spectroscopic analysis supported by high-resolution mass spectrometry. The structure revealed a rare piperidine N-oxide, not observed in filamentous fungi before. A biosynthetic pathway towards aspiperidine oxide is proposed, based on tentative identification of intermediates from UHPLC-DAD-HRMS data.
    Original languageEnglish
    JournalTetrahedron Letters
    Volume56
    Issue number14
    Pages (from-to)1847-1850
    Number of pages4
    ISSN0040-4039
    DOIs
    Publication statusPublished - 2015

    Keywords

    • Dipeptide
    • Aspergillus indologenus
    • Biosynthesis
    • N-Oxide

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