Aspects of investigating scrambling in the synthesis of porphyrins Different analytical methods

C.B. Nielsen; Frederik C Krebs

doi:10.1016/j.tetlet.2005.06.123

Aspects of investigating scrambling in the synthesis of porphyrins Different analytical methods

C.B. Nielsen, Frederik C Krebs

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Herein, we discuss the analyses and quantification of the different components in porphyrin mixtures, prepared from p-anisaidehyde, p-tolualdehyde, and 5-(4-bromophenyl)-dipyrromethane with acid catalysis, using NMR and HPLC. The advantages and disadvantages of these analytical methods are emphasized. Due to the similar size of a bromine atom and a methyl group it was possible to grow crystals suitable for X-ray crystallographic studies from a mixture of porphyrins, where the 4-position of the meso-phenyl rings was either substituted with methyl groups or bromine atoms. We also show that X-ray studies are inferior to NMR analysis for determining the components in a porphyrin mixture. (c) 2005 Elsevier Ltd. All rights reserved.

Original language	English
Journal	Tetrahedron Letters
Volume	46
Issue number	35
Pages (from-to)	5935-5939
ISSN	0040-4039
DOIs	https://doi.org/10.1016/j.tetlet.2005.06.123
Publication status	Published - 2005

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title = "Aspects of investigating scrambling in the synthesis of porphyrins Different analytical methods",

abstract = "Herein, we discuss the analyses and quantification of the different components in porphyrin mixtures, prepared from p-anisaidehyde, p-tolualdehyde, and 5-(4-bromophenyl)-dipyrromethane with acid catalysis, using NMR and HPLC. The advantages and disadvantages of these analytical methods are emphasized. Due to the similar size of a bromine atom and a methyl group it was possible to grow crystals suitable for X-ray crystallographic studies from a mixture of porphyrins, where the 4-position of the meso-phenyl rings was either substituted with methyl groups or bromine atoms. We also show that X-ray studies are inferior to NMR analysis for determining the components in a porphyrin mixture. (c) 2005 Elsevier Ltd. All rights reserved. ",

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T1 - Aspects of investigating scrambling in the synthesis of porphyrins Different analytical methods

AU - Nielsen, C.B.

AU - Krebs, Frederik C

PY - 2005

Y1 - 2005

N2 - Herein, we discuss the analyses and quantification of the different components in porphyrin mixtures, prepared from p-anisaidehyde, p-tolualdehyde, and 5-(4-bromophenyl)-dipyrromethane with acid catalysis, using NMR and HPLC. The advantages and disadvantages of these analytical methods are emphasized. Due to the similar size of a bromine atom and a methyl group it was possible to grow crystals suitable for X-ray crystallographic studies from a mixture of porphyrins, where the 4-position of the meso-phenyl rings was either substituted with methyl groups or bromine atoms. We also show that X-ray studies are inferior to NMR analysis for determining the components in a porphyrin mixture. (c) 2005 Elsevier Ltd. All rights reserved.

AB - Herein, we discuss the analyses and quantification of the different components in porphyrin mixtures, prepared from p-anisaidehyde, p-tolualdehyde, and 5-(4-bromophenyl)-dipyrromethane with acid catalysis, using NMR and HPLC. The advantages and disadvantages of these analytical methods are emphasized. Due to the similar size of a bromine atom and a methyl group it was possible to grow crystals suitable for X-ray crystallographic studies from a mixture of porphyrins, where the 4-position of the meso-phenyl rings was either substituted with methyl groups or bromine atoms. We also show that X-ray studies are inferior to NMR analysis for determining the components in a porphyrin mixture. (c) 2005 Elsevier Ltd. All rights reserved.

KW - 7-I poly

U2 - 10.1016/j.tetlet.2005.06.123

DO - 10.1016/j.tetlet.2005.06.123

M3 - Journal article

VL - 46

SP - 5935

EP - 5939

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 35

ER -