Abstract
Described herein are variants of arylalkylamine N-acetyltransferase (AANAT) as well as vectors and recombinant microbial host cells expressing AANATs and variant AANATs and their use in producing N-acetylserotonin, melatonin and related compounds. Preferred AANAT variants provide for an increased yield of N-acetylserotonin.
| Original language | English |
|---|---|
| IPC | C12N9/10; C12N15/00; C12N5/00 |
| Patent number | WO2018108966 |
| Filing date | 21/06/2018 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 13/12/2016 |
| Priority number | EP20160203711 |
| Publication status | Published - 2018 |