Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices

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Abstract

Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection,enables accelerated, real-time characterization of ODD devices.
Original languageEnglish
Publication date2019
Number of pages2
Publication statusPublished - 2019
EventThe 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019/microtas 2019) - Congress Center Basel, Basel, Switzerland
Duration: 27 Oct 201931 Oct 2019
Conference number: 23
https://www.microtas2019.org/
https://microtas2019.org/

Conference

ConferenceThe 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2019/microtas 2019)
Number23
LocationCongress Center Basel
CountrySwitzerland
CityBasel
Period27/10/201931/10/2019
Internet address

Keywords

  • Lab-on-a-disc
  • Oral drug delivery devices
  • Microcontainers
  • Event-triggered valves

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