Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices

Sriram Thoppe Rajendran; Khorshid Kamguyan; David Kinahan; En-Te Hwu; Line Hagner Nielsen; Kinga Zór; Anja Boisen

Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices

Sriram Thoppe Rajendran, Khorshid Kamguyan, David Kinahan, En-Te Hwu, Line Hagner Nielsen, Kinga Zór, Anja Boisen

Dublin City University

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

Abstract

Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection,enables accelerated, real-time characterization of ODD devices.

Original language	English
Publication date	2019
Number of pages	2
Publication status	Published - 2019
Event	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences - Congress Center Basel, Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 Conference number: 23 https://www.microtas2019.org/

Conference

Conference	23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Number	23
Location	Congress Center Basel
Country/Territory	Switzerland
City	Basel
Period	27/10/2019 → 31/10/2019
Internet address	https://www.microtas2019.org/

Keywords

Lab-on-a-disc
Oral drug delivery devices
Microcontainers
Event-triggered valves

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences
Thoppe Rajendran, S. (Organizer)
27 Oct 2019 → 31 Oct 2019
Activity: Attending an event › Participating in or organising a conference

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title = "Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices",

abstract = "Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining {\textquoteleft}event-triggered{\textquoteright} flow control, based on dissolvable film with electrochemical detection,enables accelerated, real-time characterization of ODD devices.",

keywords = "Lab-on-a-disc, Oral drug delivery devices, Microcontainers, Event-triggered valves",

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year = "2019",

language = "English",

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Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices. / Thoppe Rajendran, Sriram; Kamguyan, Khorshid; Kinahan, David et al.
2019. Abstract from 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, Basel, Switzerland.

Research output: Contribution to conference › Conference abstract for conference › Research › peer-review

TY - ABST

T1 - Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices

AU - Thoppe Rajendran, Sriram

AU - Kamguyan, Khorshid

AU - Kinahan, David

AU - Hwu, En-Te

AU - Nielsen, Line Hagner

AU - Zór, Kinga

AU - Boisen, Anja

N1 - Conference code: 23

PY - 2019

Y1 - 2019

N2 - Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection,enables accelerated, real-time characterization of ODD devices.

AB - Rapid testing of pH coatings of oral drug delivery (ODD) devices is often complex and time consuming. A lab-on-a-disc (LoD) platform was developed which enables detection of integrity of pH coatings for up to four different pHs. The platform was designed to perfuse ODD devices through different pH in a sequential manner, mimicking the pH variations in the gastrointestinal (GI) tract. The disintegration of pH coatings causes release of drugs, which in turn is used to monitor integrity of pH coatings. Combining ‘event-triggered’ flow control, based on dissolvable film with electrochemical detection,enables accelerated, real-time characterization of ODD devices.

KW - Lab-on-a-disc

KW - Oral drug delivery devices

KW - Microcontainers

KW - Event-triggered valves

M3 - Conference abstract for conference

T2 - 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

Y2 - 27 October 2019 through 31 October 2019

ER -

Artificial gut-on-a-disc platform to evaluate ph sensitive coatings of oral drug delivery devices

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Keywords

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23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences

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