TY - JOUR
T1 - Articular Cartilage Thickness Measured with US is Not as Easy as It Appears
T2 - A Systematic Review of Measurement Techniques and Image Interpretation
AU - Torp-Pedersen, Søren
AU - Bartels, E. M.
AU - Wilhjelm, Jens E.
AU - Bliddal, H.
PY - 2011
Y1 - 2011
N2 - Background: Theoretically, the high spatial resolution
of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis.
A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage ismeasured under orthogonal insonation. If US measurements are compared to measurements with other techniques, they
should be corrected for the higher sound speed in cartilage.
Purpose: To study whether investigators correctly
identify the articular cartilage, whether they insonate orthogonally, and whether they correct for sound speed.
Materials and Methods: A literature search limited to the last 10 years of studies applying US to measure cartilage thickness. Results: 15 studies were identified and they referred to another 8 studies describing methods of
thickness measurement. 11 of the 15 studies identified the superficial cartilage border incorrectly, and 6 applied oblique insonation. 2 of the 15 studies corrected for sound speed. Of the further 8 studies, one might correctly identify the superficial cartilage border, 4 applied oblique insonation, and none corrected for sound speed.
Conclusion: We found that the majority of studies over the last 10 years, evaluating articular cartilage thickness with US, underestimated the cartilage thickness by not including the leading interface as part of the cartilage. Since the cartilage is relatively thin, this error is substantial. Some investigators also overestimated cartilage
thickness by using oblique insonation of the cartilage.
By not correcting for the high sound speed in cartilage, most investigators underestimated the cartilage thickness.
AB - Background: Theoretically, the high spatial resolution
of US makes it well suited to monitor the decrease in articular cartilage thickness in osteoarthritis.
A requirement is, however, that the borders of the cartilage are correctly identified and that the cartilage ismeasured under orthogonal insonation. If US measurements are compared to measurements with other techniques, they
should be corrected for the higher sound speed in cartilage.
Purpose: To study whether investigators correctly
identify the articular cartilage, whether they insonate orthogonally, and whether they correct for sound speed.
Materials and Methods: A literature search limited to the last 10 years of studies applying US to measure cartilage thickness. Results: 15 studies were identified and they referred to another 8 studies describing methods of
thickness measurement. 11 of the 15 studies identified the superficial cartilage border incorrectly, and 6 applied oblique insonation. 2 of the 15 studies corrected for sound speed. Of the further 8 studies, one might correctly identify the superficial cartilage border, 4 applied oblique insonation, and none corrected for sound speed.
Conclusion: We found that the majority of studies over the last 10 years, evaluating articular cartilage thickness with US, underestimated the cartilage thickness by not including the leading interface as part of the cartilage. Since the cartilage is relatively thin, this error is substantial. Some investigators also overestimated cartilage
thickness by using oblique insonation of the cartilage.
By not correcting for the high sound speed in cartilage, most investigators underestimated the cartilage thickness.
U2 - 10.1055/s-0029-1245386
DO - 10.1055/s-0029-1245386
M3 - Journal article
C2 - 20645223
SN - 0172-4614
VL - 32
SP - 54
EP - 61
JO - Ultraschall in der Medizin
JF - Ultraschall in der Medizin
IS - 1
ER -